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Itpk1 Gene Detail
Summary
  • Symbol
    Itpk1
  • Name
    inositol 1,3,4-triphosphate 5/6 kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446159
    NCBI Gene: 217837
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:102534842-102671128 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 51.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3761 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446159
 protein coding gene Chr12:102534841-102671189 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020034
 protein coding gene Chr12:104205328-104354406 (-)
A/J MGP_AJ_G0019990
 protein coding gene Chr12:100209058-100344227 (-)
AKR/J MGP_AKRJ_G0019966
 protein coding gene Chr12:103051284-103186186 (-)
BALB/cJ MGP_BALBcJ_G0019976
 protein coding gene Chr12:100557049-100695957 (-)
C3H/HeJ MGP_C3HHeJ_G0019778
 protein coding gene Chr12:103508929-103655059 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020425
 protein coding gene Chr12:107452569-107594717 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018038
 protein coding gene Chr12:97220804-97357246 (-)
CAST/EiJ MGP_CASTEiJ_G0019324
 protein coding gene Chr12:98349468-98493715 (-)
CBA/J MGP_CBAJ_G0019750
 protein coding gene Chr12:111441066-111592566 (-)
DBA/2J MGP_DBA2J_G0019861
 protein coding gene Chr12:99721968-99859379 (-)
FVB/NJ MGP_FVBNJ_G0019850
 protein coding gene Chr12:98451384-98590202 (-)
LP/J MGP_LPJ_G0019937
 protein coding gene Chr12:104055851-104195955 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019890
 protein coding gene Chr12:114912414-115057705 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020454
 protein coding gene Chr12:102549294-102699589 (-)
PWK/PhJ MGP_PWKPhJ_G0019087
 protein coding gene Chr12:94279616-94418261 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018883
 protein coding gene Chr12:96731419-96883190 (-)
WSB/EiJ MGP_WSBEiJ_G0019378
 protein coding gene Chr12:103441658-103586927 (-)



Homology
more
  • Human Ortholog
    ITPK1, inositol-tetrakisphosphate 1-kinase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITPK1, inositol-tetrakisphosphate 1-kinase
  • Synonyms
    ITRPK1
  • Links
    NCBI Gene ID: 3705
    neXtProt AC: NX_Q13572
    UniProt: Q13572

  • Chr Location
    14q32.12; chr14:92936914-93116320 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    1 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Some mice homozygous for a gene trap allele exhibit neural tube defects (exencephaly and spina bifida), growth retardation, kyphoscoliosis, and rib formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    959
  • Tissues
    136
  • cDNA Data
    11
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 217837 NCBI Gene Model | MGI Sequence Detail 136287 C57BL/6J ±  kb
    transcript NM_172584 RefSeq | MGI Sequence Detail 2856 C57BL/6  
    polypeptide Q8BYN3 UniProt | EBI | MGI Sequence Detail 419 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 3
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory