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Farp1 Gene Detail
Summary
  • Symbol
    Farp1
  • Name
    FERM, ARH/RhoGEF and pleckstrin domain protein 1
  • Synonyms
    Cdep
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446173
    NCBI Gene: 223254
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:121272612-121521156 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 64.86 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    8166 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446173
 protein coding gene Chr14:121272563-121521156 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021660
 protein coding gene Chr14:118792646-119067617 (+)
A/J MGP_AJ_G0021620
 protein coding gene Chr14:114236296-114486518 (+)
AKR/J MGP_AKRJ_G0021596
 protein coding gene Chr14:117922253-118186609 (+)
BALB/cJ MGP_BALBcJ_G0021626
 protein coding gene Chr14:114773434-115023253 (+)
C3H/HeJ MGP_C3HHeJ_G0021404
 protein coding gene Chr14:117813852-118079645 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022066
 protein coding gene Chr14:123381411-123668476 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019604
 protein coding gene Chr14:110135967-110382521 (+)
CAST/EiJ MGP_CASTEiJ_G0020919
 protein coding gene Chr14:115698714-115966651 (+)
CBA/J MGP_CBAJ_G0021372
 protein coding gene Chr14:128085083-128366412 (+)
DBA/2J MGP_DBA2J_G0021495
 protein coding gene Chr14:114108027-114358948 (+)
FVB/NJ MGP_FVBNJ_G0021473
 protein coding gene Chr14:112430181-112685918 (+)
LP/J MGP_LPJ_G0021563
 protein coding gene Chr14:119763869-120033270 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021500
 protein coding gene Chr14:133123953-133397163 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022089
 protein coding gene Chr14:117466631-117739910 (+)
PWK/PhJ MGP_PWKPhJ_G0020663
 protein coding gene Chr14:111145966-111397294 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020501
 protein coding gene Chr14:113695987-113950536 (+)
WSB/EiJ MGP_WSBEiJ_G0020975
 protein coding gene Chr14:118181138-118448053 (+)



Homology
more
  • Human Ortholog
    FARP1, FERM, ARH/RhoGEF and pleckstrin domain protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FARP1, FERM, ARH/RhoGEF and pleckstrin domain protein 1
  • Synonyms
    CDEP, FARP1-IT1, GLCC1, PLEKHC2, PPP1R75
  • Links
    NCBI Gene ID: 10160
    neXtProt AC: NX_Q9Y4F1
    UniProt: Q9Y4F1

  • Chr Location
    13q32.2; chr13:98142562-98455176 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    32
  • cDNA Data
    143
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025555 Ensembl Gene Model | MGI Sequence Detail 248545 C57BL/6J ±  kb
    transcript ENSMUST00000026635 Ensembl | MGI Sequence Detail 4885 Not Applicable  
    polypeptide ENSMUSP00000026635 Ensembl | MGI Sequence Detail 1048 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 144
      cDNA 143
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145808
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:86639 Luo ZG, et al., Implication of geranylgeranyltransferase I in synapse formation. Neuron. 2003 Nov 13;40(4):703-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory