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Dnd1 Gene Detail
Summary
  • Symbol
    Dnd1
  • Name
    DND microRNA-mediated repression inhibitor 1
  • Synonyms
    MGC:41452, RBMS4, Ter
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447763
    NCBI Gene: 213236
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:36896724-36899267 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.46 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2447763
 protein coding gene Chr18:36896724-36899267 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024290
 protein coding gene Chr18:35176726-35179296 (-)
A/J MGP_AJ_G0024256
 protein coding gene Chr18:33937716-33940251 (-)
AKR/J MGP_AKRJ_G0024224
 protein coding gene Chr18:34892765-34895300 (-)
BALB/cJ MGP_BALBcJ_G0024256
 protein coding gene Chr18:33986859-33989397 (-)
C3H/HeJ MGP_C3HHeJ_G0024023
 protein coding gene Chr18:34956684-34959222 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024697
 protein coding gene Chr18:36413367-36415908 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022137
 protein coding gene Chr18:34031616-34034130 (-)
CAST/EiJ MGP_CASTEiJ_G0023498
 protein coding gene Chr18:34971548-34975078 (-)
CBA/J MGP_CBAJ_G0023991
 protein coding gene Chr18:37490975-37493511 (-)
DBA/2J MGP_DBA2J_G0024123
 protein coding gene Chr18:33554841-33557378 (-)
FVB/NJ MGP_FVBNJ_G0024090
 protein coding gene Chr18:33264491-33267501 (-)
LP/J MGP_LPJ_G0024205
 protein coding gene Chr18:35210939-35213492 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024118
 protein coding gene Chr18:38705060-38707599 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024746
 protein coding gene Chr18:34763156-34765694 (-)
PWK/PhJ MGP_PWKPhJ_G0023242
 protein coding gene Chr18:33816057-33818756 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023049
 protein coding gene Chr18:35015577-35018105 (-)
WSB/EiJ MGP_WSBEiJ_G0023561
 protein coding gene Chr18:34682876-34685415 (-)



Homology
more
  • Human Ortholog
    DND1, DND microRNA-mediated repression inhibitor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DND1, DND microRNA-mediated repression inhibitor 1
  • Synonyms
    RBMS4
  • Links
    NCBI Gene ID: 373863
    neXtProt AC: NX_Q8IYX4
    UniProt: Q8IYX4

  • Chr Location
    5q31.3; chr5:140670794-140673576 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 6 genetic backgrounds
    5 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A semidominant mutation in the 129/Sv strain markedly increases the frequency of testicular teratomas. Homozygous males are germ cell deficient and sterile, while homozygous females have small ovaries, but usually breed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    49
  • cDNA Data
    5
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 213236 NCBI Gene Model | MGI Sequence Detail 2544 C57BL/6J ±  kb
    transcript NM_173383 RefSeq | MGI Sequence Detail 1490 ZRU/MplStud  
    polypeptide Q6VY05 UniProt | EBI | MGI Sequence Detail 352 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 6
      Primer pair 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-15041, MGI:98710
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 14
      Gene Ontology 7
      Phenotypes 47
    • Earliest
      J:26336 Stevens LC, et al., Spontaneous Testicular Teratomas in an Inbred Strain of Mice. Proc Natl Acad Sci U S A. 1954 Nov;40(11):1080-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory