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Egfl7 Gene Detail
Summary
  • Symbol
    Egfl7
  • Name
    EGF-like domain 7
  • Synonyms
    vascular endothelial-statin, VE-statin, Zneu1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449923
    NCBI Gene: 353156
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:26471095-26482694 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 18.95 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    385 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449923
 protein coding gene Chr2:26470026-26483132 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025491
 protein coding gene Chr2:24539502-24554156 (+)
A/J MGP_AJ_G0025468
 protein coding gene Chr2:23599436-23612502 (+)
AKR/J MGP_AKRJ_G0025438
 protein coding gene Chr2:24362235-24375310 (+)
BALB/cJ MGP_BALBcJ_G0025464
 protein coding gene Chr2:23709816-23723014 (+)
C3H/HeJ MGP_C3HHeJ_G0025225
 protein coding gene Chr2:24324651-24338932 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025908
 protein coding gene Chr2:25337417-25353562 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023319
 protein coding gene Chr2:22477687-22490825 (+)
CAST/EiJ MGP_CASTEiJ_G0024688
 protein coding gene Chr2:24200912-24215660 (+)
CBA/J MGP_CBAJ_G0025203
 protein coding gene Chr2:26183092-26197838 (+)
DBA/2J MGP_DBA2J_G0025336
 protein coding gene Chr2:23419934-23433022 (+)
FVB/NJ MGP_FVBNJ_G0025298
 protein coding gene Chr2:23176880-23190307 (+)
LP/J MGP_LPJ_G0025422
 protein coding gene Chr2:24480251-24497972 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025329
 protein coding gene Chr2:26327499-26340566 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025967
 protein coding gene Chr2:24319991-24333094 (+)
PWK/PhJ MGP_PWKPhJ_G0024436
 protein coding gene Chr2:23228047-23241132 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024236
 protein coding gene Chr2:24456195-24471599 (+)
WSB/EiJ MGP_WSBEiJ_G0024757
 protein coding gene Chr2:24427751-24441957 (+)



Homology
more
  • Human Ortholog
    EGFL7, EGF like domain multiple 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EGFL7, EGF like domain multiple 7
  • Synonyms
    NEU1, VE-STATIN, ZNEU1
  • Links
    NCBI Gene ID: 51162
    neXtProt AC: NX_Q9UHF1
    UniProt: Q9UHF1

  • Chr Location
    9q34.3; chr9:136658856-136672678 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 4 alleles in 4 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit some embryonic lethality with absent heartbeat and systemic edema, delayed vasculogenesis, decreased angiogenesis, abnormal adult vasculature, and low-level hypoxia. Mice homozygous for a null allele that does not disrupt Mirn126 expression are normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    966
  • Tissues
    140
  • cDNA Data
    68
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 353156 NCBI Gene Model | MGI Sequence Detail 11600 C57BL/6J ±  kb
    transcript NM_198724 RefSeq | MGI Sequence Detail 1387 C57BL/6  
    polypeptide Q9QXT5 UniProt | EBI | MGI Sequence Detail 275 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 76
      cDNA 70
      Primer pair 6

      Microarray probesets 4
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 22
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:47981 Xiong JW, et al., Large-scale screening for developmental genes in embryonic stem cells and embryoid bodies using retroviral entrapment vectors. Dev Dyn. 1998 Jun;212(2):181-97
    • Latest
      J:330449 Rusidze M, et al., Loss of function of the maternal membrane oestrogen receptor ERalpha alters expansion of trophoblast cells and impacts mouse fertility. Development. 2022 Oct 1;149(19):dev200683
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory