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Arhgap32 Gene Detail
Summary
  • Symbol
    Arhgap32
  • Name
    Rho GTPase activating protein 32
  • Synonyms
    3426406O18Rik, GC-GAP, Grit, p200RhoGAP, PX-RICS
  • Feature Type
    protein coding gene
  • IDs
    MGI:2450166
    NCBI Gene: 330914
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:32027432-32179742 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 17.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3440 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2450166
 protein coding gene Chr9:31927921-32179742 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034522
 protein coding gene Chr9:29846676-30009691 (+)
A/J MGP_AJ_G0034500
 protein coding gene Chr9:29085485-29241519 (+)
AKR/J MGP_AKRJ_G0034426
 protein coding gene Chr9:29714026-29875816 (+)
BALB/cJ MGP_BALBcJ_G0034491
 protein coding gene Chr9:28979527-29133187 (+)
C3H/HeJ MGP_C3HHeJ_G0034203
 protein coding gene Chr9:30058368-30220556 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035012
 protein coding gene Chr9:30863526-31029279 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031942
 protein coding gene Chr9:27887623-28038628 (+)
CAST/EiJ MGP_CASTEiJ_G0033526
 protein coding gene Chr9:29893460-30083335 (+)
CBA/J MGP_CBAJ_G0034177
 protein coding gene Chr9:31875578-32057634 (+)
DBA/2J MGP_DBA2J_G0034334
 protein coding gene Chr9:29097354-29250308 (+)
FVB/NJ MGP_FVBNJ_G0034277
 protein coding gene Chr9:28499217-28653600 (+)
LP/J MGP_LPJ_G0034420
 protein coding gene Chr9:30060996-30229422 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034321
 protein coding gene Chr9:33510356-33689002 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035032
 protein coding gene Chr9:29698787-29864058 (+)
PWK/PhJ MGP_PWKPhJ_G0033231
 protein coding gene Chr9:29048820-29209273 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033066
 protein coding gene Chr9:29817278-29975270 (+)
WSB/EiJ MGP_WSBEiJ_G0033641
 protein coding gene Chr9:29448789-29611863 (+)



Homology
more
  • Human Ortholog
    ARHGAP32, Rho GTPase activating protein 32
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGAP32, Rho GTPase activating protein 32
  • Synonyms
    GC-GAP, GRIT, p200RhoGAP, p250GAP, PX-RICS, RICS
  • Links
    NCBI Gene ID: 9743
    neXtProt AC: NX_A7KAX9
    UniProt: A7KAX9

  • Chr Location
    11q24.3; chr11:128965060-129279632 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Arhgap32 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation are fertile but display abnormal neurite growth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    18
  • cDNA Data
    35
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041444 Ensembl Gene Model | MGI Sequence Detail 152311 C57BL/6J ±  kb
transcript ENSMUST00000174641 Ensembl | MGI Sequence Detail 13568 Not Applicable  
polypeptide ENSMUSP00000133898 Ensembl | MGI Sequence Detail 2089 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    cDNA 35

    Microarray probesets 3
Other
Accession IDs
less
MGI:1917927
References
more
  • Summaries
    All 48
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:236753 Nakamura T, et al., PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking. Nat Commun. 2016 Mar 16;7:10861
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory