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Pde5a Gene Detail
Summary
  • Symbol
    Pde5a
  • Name
    phosphodiesterase 5A, cGMP-specific
  • Synonyms
    Pde5, PDE5A1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2651499
    NCBI Gene: 242202
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:122522822-122653023 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 53.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3921 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2651499
 protein coding gene Chr3:122522596-122653023 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027841
 protein coding gene Chr3:125010844-125148928 (+)
A/J MGP_AJ_G0027799
 protein coding gene Chr3:120826021-120959633 (+)
AKR/J MGP_AKRJ_G0027765
 protein coding gene Chr3:123907626-124044240 (+)
BALB/cJ MGP_BALBcJ_G0027811
 protein coding gene Chr3:120637938-120775000 (+)
C3H/HeJ MGP_C3HHeJ_G0027542
 protein coding gene Chr3:124301155-124442784 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028257
 protein coding gene Chr3:129541003-129687993 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025596
 protein coding gene Chr3:116257682-116385994 (+)
CAST/EiJ MGP_CASTEiJ_G0026998
 protein coding gene Chr3:123697649-123838975 (+)
CBA/J MGP_CBAJ_G0027517
 protein coding gene Chr3:133928526-134067747 (+)
DBA/2J MGP_DBA2J_G0027658
 protein coding gene Chr3:119955624-120084245 (+)
FVB/NJ MGP_FVBNJ_G0027626
 protein coding gene Chr3:117568950-117701772 (+)
LP/J MGP_LPJ_G0027768
 protein coding gene Chr3:126524953-126665411 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027656
 protein coding gene Chr3:141479537-141620020 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028313
 protein coding gene Chr3:123463129-123607237 (+)
PWK/PhJ MGP_PWKPhJ_G0026724
 protein coding gene Chr3:119677218-119808751 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026547
 protein coding gene Chr3:121571873-121703936 (+)
WSB/EiJ MGP_WSBEiJ_G0027078
 protein coding gene Chr3:124198005-124338506 (+)



Homology
more
  • Human Ortholog
    PDE5A, phosphodiesterase 5A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE5A, phosphodiesterase 5A
  • Synonyms
    CGB-PDE, CN5A, PDE5
  • Links
    NCBI Gene ID: 8654
    neXtProt AC: NX_O76074
    UniProt: O76074

  • Chr Location
    4q26; chr4:119494397-119628804 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PDE5A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with a mutation that prevents luteinizing hormone-induced phosphorylation are viable, fertile and show no obvious morphological or behavioral abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    921
  • Tissues
    106
  • cDNA Data
    31
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 242202 NCBI Gene Model | MGI Sequence Detail 130202 C57BL/6J ±  kb
    transcript NM_001409793 RefSeq | MGI Sequence Detail 7031 C57BL/6  
    polypeptide Q8CG03 UniProt | EBI | MGI Sequence Detail 865 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 31
      Primer pair 3

      Microarray probesets 1
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 14
      Phenotypes 12
    • Earliest
      J:49444 Loughney K, et al., Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase. Gene. 1998 Aug 17;216(1):139-47
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory