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Plekhg5 Gene Detail
Summary
  • Symbol
    Plekhg5
  • Name
    pleckstrin homology domain containing, family G (with RhoGef domain) member 5
  • Synonyms
    mKIAA0720, Syx1, Syx2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2652860
    NCBI Gene: 269608
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:152156955-152199857 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 82.86 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1362 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2652860
 protein coding gene Chr4:152156890-152199857 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029171
 protein coding gene Chr4:156186506-156215088 (+)
A/J MGP_AJ_G0029136
 protein coding gene Chr4:149627247-149656197 (+)
AKR/J MGP_AKRJ_G0029084
 protein coding gene Chr4:153702556-153730919 (+)
BALB/cJ MGP_BALBcJ_G0029152
 protein coding gene Chr4:150108522-150138027 (+)
C3H/HeJ MGP_C3HHeJ_G0028873
 protein coding gene Chr4:154268199-154299973 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029601
 protein coding gene Chr4:161781300-161809834 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026847
 protein coding gene Chr4:141989108-142018332 (+)
CAST/EiJ MGP_CASTEiJ_G0028286
 protein coding gene Chr4:151594069-151642796 (+)
CBA/J MGP_CBAJ_G0028835
 protein coding gene Chr4:166596486-166624961 (+)
DBA/2J MGP_DBA2J_G0028984
 protein coding gene Chr4:149688726-149717429 (+)
FVB/NJ MGP_FVBNJ_G0028948
 protein coding gene Chr4:148843280-148872329 (+)
LP/J MGP_LPJ_G0029074
 protein coding gene Chr4:156102457-156130974 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028975
 protein coding gene Chr4:169636064-169665684 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029633
 protein coding gene Chr4:154246455-154276091 (+)
PWK/PhJ MGP_PWKPhJ_G0028006
 protein coding gene Chr4:145742579-145788711 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027840
 protein coding gene Chr4:148526134-148557172 (+)
WSB/EiJ MGP_WSBEiJ_G0028366
 protein coding gene Chr4:154411313-154441100 (+)



Homology
more
  • Human Ortholog
    PLEKHG5, pleckstrin homology and RhoGEF domain containing G5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHG5, pleckstrin homology and RhoGEF domain containing G5
  • Synonyms
    ARHGEF45, CMTRIC, DSMA4, GEF720, HMNR4, Syx, Tech
  • Links
    NCBI Gene ID: 57449
    neXtProt AC: NX_O94827
    UniProt: O94827

  • Chr Location
    1p36.31; chr1:6467122-6520092 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PLEKHG5 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display angiogenic defects that affect multiple organs, including sparser coronary and kidney arterial systems that appear to deficient in small diameter vessels while the major coronary and kidney arteries remain intact.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    11
  • cDNA Data
    8
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039713 Ensembl Gene Model | MGI Sequence Detail 42903 C57BL/6J ±  kb
    transcript ENSMUST00000239025 Ensembl | MGI Sequence Detail 3312 Not Applicable  
    polypeptide ENSMUSP00000158992 Ensembl | MGI Sequence Detail 1103 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:355213 Hutchings AJ, et al., Plekhg5 controls the unconventional secretion of Sod1 by presynaptic secretory autophagy. Nat Commun. 2024 Oct 4;15(1):8622
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory