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Dtx3l Gene Detail
Summary
  • Symbol
    Dtx3l
  • Name
    deltex 3-like, E3 ubiquitin ligase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2656973
    NCBI Gene: 209200
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:35746885-35759397 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 25.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    237 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2656973
protein coding gene Chr16:35746881-35759521 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022773
protein coding gene Chr16:34278395-34291844 (-)
A/J MGP_AJ_G0022738
protein coding gene Chr16:32616216-32629396 (-)
AKR/J MGP_AKRJ_G0022711
protein coding gene Chr16:33758705-33772312 (-)
BALB/cJ MGP_BALBcJ_G0022740
protein coding gene Chr16:32739393-32751930 (-)
C3H/HeJ MGP_C3HHeJ_G0022505
protein coding gene Chr16:33887265-33899786 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023189
protein coding gene Chr16:35013145-35027492 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020707
protein coding gene Chr16:32971563-32984284 (-)
CAST/EiJ MGP_CASTEiJ_G0022033
protein coding gene Chr16:34114874-34127467 (-)
CBA/J MGP_CBAJ_G0022475
protein coding gene Chr16:36437888-36450404 (-)
DBA/2J MGP_DBA2J_G0022608
protein coding gene Chr16:32440394-32452918 (-)
FVB/NJ MGP_FVBNJ_G0022583
protein coding gene Chr16:32437219-32449735 (-)
LP/J MGP_LPJ_G0022675
protein coding gene Chr16:34009479-34022005 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022602
protein coding gene Chr16:35709500-35722683 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023201
protein coding gene Chr16:33815363-33827979 (-)
PWK/PhJ MGP_PWKPhJ_G0021774
protein coding gene Chr16:32851779-32864371 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021605
protein coding gene Chr16:33631589-33646889 (-)
WSB/EiJ MGP_WSBEiJ_G0022077
protein coding gene Chr16:33741385-33756112 (-)



Homology
more
  • Human Ortholog
    DTX3L, deltex E3 ubiquitin ligase 3L
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DTX3L, deltex E3 ubiquitin ligase 3L
  • Synonyms
    BBAP, RNF143
  • Links
    NCBI Gene ID: 151636
    neXtProt AC: NX_Q8TDB6
    UniProt: Q8TDB6

  • Chr Location
    3q21.1; chr3:122564338-122575203 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 209200 NCBI Gene Model | MGI Sequence Detail 12513 C57BL/6J ±  kb
    transcript NM_001013371 RefSeq | MGI Sequence Detail 5181 C57BL/6  
    polypeptide Q3UIR3 UniProt | EBI | MGI Sequence Detail 748 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 50

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:3035479
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/29/2024
    MGI 6.24
    The Jackson Laboratory