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Mppe1 Gene Detail
Summary
  • Symbol
    Mppe1
  • Name
    metallophosphoesterase 1
  • Synonyms
    Pgap5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2661311
    NCBI Gene: 225651
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:67358119-67378901 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 39.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    691 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2661311
 protein coding gene Chr18:67358114-67378901 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024520
 protein coding gene Chr18:67491983-67515043 (-)
A/J MGP_AJ_G0024487
 protein coding gene Chr18:64543483-64564941 (-)
AKR/J MGP_AKRJ_G0024457
 protein coding gene Chr18:66441968-66466453 (-)
BALB/cJ MGP_BALBcJ_G0024486
 protein coding gene Chr18:64710487-64734962 (-)
C3H/HeJ MGP_C3HHeJ_G0024254
 protein coding gene Chr18:66598426-66622242 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024933
 protein coding gene Chr18:69285540-69310340 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022364
 protein coding gene Chr18:63926783-63947854 (-)
CAST/EiJ MGP_CASTEiJ_G0023727
 protein coding gene Chr18:66585179-66608194 (-)
CBA/J MGP_CBAJ_G0024224
 protein coding gene Chr18:71659669-71685882 (-)
DBA/2J MGP_DBA2J_G0024354
 protein coding gene Chr18:64203936-64224283 (-)
FVB/NJ MGP_FVBNJ_G0024320
 protein coding gene Chr18:63574467-63595884 (-)
LP/J MGP_LPJ_G0024438
 protein coding gene Chr18:67356064-67377091 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024349
 protein coding gene Chr18:72945999-72969452 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024980
 protein coding gene Chr18:66605584-66627651 (-)
PWK/PhJ MGP_PWKPhJ_G0023470
 protein coding gene Chr18:64477836-64498531 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023275
 protein coding gene Chr18:66756041-66776234 (-)
WSB/EiJ MGP_WSBEiJ_G0023791
 protein coding gene Chr18:66483643-66511375 (-)



Homology
more
  • Human Ortholog
    MPPE1, metallophosphoesterase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MPPE1, metallophosphoesterase 1
  • Synonyms
    Cdc1, PGAP5
  • Links
    NCBI Gene ID: 65258
    neXtProt AC: NX_Q53F39
    UniProt: Q53F39

  • Chr Location
    18p11.21; chr18:11882622-11908366 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    12
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 225651 NCBI Gene Model | MGI Sequence Detail 20783 C57BL/6J ±  kb
transcript NM_172630 RefSeq | MGI Sequence Detail 2506 C57BL/6  
polypeptide Q80XL7 UniProt | EBI | MGI Sequence Detail 396 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 2
References
more
  • Summaries
    All 26
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory