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Tmc8 Gene Detail
Summary
  • Symbol
    Tmc8
  • Name
    transmembrane channel-like gene family 8
  • Synonyms
    Ever2, EVIN2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2669037
    NCBI Gene: 217356
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:117672902-117683936 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 82.96 cM
Strain
Comparison
more
  • SNPs within 2kb
    417 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2669037
 protein coding gene Chr11:117672396-117683963 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019450
 protein coding gene Chr11:122063019-122074108 (+)
A/J MGP_AJ_G0019418
 protein coding gene Chr11:116652314-116663390 (+)
AKR/J MGP_AKRJ_G0019388
 protein coding gene Chr11:120201443-120214163 (+)
BALB/cJ MGP_BALBcJ_G0019393
 protein coding gene Chr11:117024462-117036040 (+)
C3H/HeJ MGP_C3HHeJ_G0019199
 protein coding gene Chr11:120480556-120491621 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019842
 protein coding gene Chr11:125783793-125796425 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017467
 protein coding gene Chr11:113660580-113672408 (+)
CAST/EiJ MGP_CASTEiJ_G0018753
 protein coding gene Chr11:121914914-121926053 (+)
CBA/J MGP_CBAJ_G0019170
 protein coding gene Chr11:130742075-130755556 (+)
DBA/2J MGP_DBA2J_G0019282
 protein coding gene Chr11:116052784-116064716 (+)
FVB/NJ MGP_FVBNJ_G0019274
 protein coding gene Chr11:115673355-115685189 (+)
LP/J MGP_LPJ_G0019352
 protein coding gene Chr11:122385909-122397753 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019307
 protein coding gene Chr11:129704908-129715933 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019881
 protein coding gene Chr11:120850009-120861152 (+)
PWK/PhJ MGP_PWKPhJ_G0018519
 protein coding gene Chr11:117409997-117421196 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018311
 protein coding gene Chr11:120581971-120593924 (+)
WSB/EiJ MGP_WSBEiJ_G0018805
 protein coding gene Chr11:120819820-120831631 (+)



Homology
more
  • Human Ortholog
    TMC8, transmembrane channel like 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMC8, transmembrane channel like 8
  • Synonyms
    EV2, EVER2, EVIN2
  • Links
    NCBI Gene ID: 147138
    neXtProt AC: NX_Q8IU68
    UniProt: Q8IU68

  • Chr Location
    17q25.3; chr17:78130770-78142968 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TMC8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, fertile and overtly normal with no major defects in T cell subset numbers or function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    15
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050106 Ensembl Gene Model | MGI Sequence Detail 11035 C57BL/6J ±  kb
transcript ENSMUST00000106334 Ensembl | MGI Sequence Detail 2644 Not Applicable  
polypeptide ENSMUSP00000101941 Ensembl | MGI Sequence Detail 723 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 2
    cDNA 15

    Microarray probesets 2
References
more
  • Summaries
    All 36
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:84240 Keresztes G, et al., TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. BMC Genomics. 2003 Jun 17;4(1):24
  • Latest
    J:354201 Torres AD, et al., Deficiency in Ever2 does not increase susceptibility of mice to pathogenesis by the mouse papillomavirus, MmuPV1. J Virol. 2024 Jul 23;98(7):e0017424
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory