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Bsx Gene Detail
Summary
  • Symbol
    Bsx
  • Name
    brain specific homeobox
  • Synonyms
    Bsx1a, Bsx1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2669849
    NCBI Gene: 244813
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:40785423-40791353 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 21.65 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    216 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2669849
 protein coding gene Chr9:40782994-40791353 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034671
 protein coding gene Chr9:39125938-39129827 (+)
A/J MGP_AJ_G0034651
 protein coding gene Chr9:38114503-38118392 (+)
AKR/J MGP_AKRJ_G0034577
 protein coding gene Chr9:38832781-38836668 (+)
BALB/cJ MGP_BALBcJ_G0034642
 protein coding gene Chr9:37857773-37861662 (+)
C3H/HeJ MGP_C3HHeJ_G0034353
 protein coding gene Chr9:39358026-39361916 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035165
 protein coding gene Chr9:40370001-40373810 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032078
 protein coding gene Chr9:37740044-37743783 (+)
CAST/EiJ MGP_CASTEiJ_G0033676
 protein coding gene Chr9:39083884-39087687 (+)
CBA/J MGP_CBAJ_G0034326
 protein coding gene Chr9:41757493-41761380 (+)
DBA/2J MGP_DBA2J_G0034485
 protein coding gene Chr9:38047317-38051204 (+)
FVB/NJ MGP_FVBNJ_G0034425
 protein coding gene Chr9:37271236-37275126 (+)
LP/J MGP_LPJ_G0034566
 protein coding gene Chr9:39400629-39404516 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034469
 protein coding gene Chr9:43807193-43811081 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035184
 protein coding gene Chr9:38758144-38762031 (+)
PWK/PhJ MGP_PWKPhJ_G0033381
 protein coding gene Chr9:37859606-37863422 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033217
 protein coding gene Chr9:38985718-38989496 (+)
WSB/EiJ MGP_WSBEiJ_G0033789
 protein coding gene Chr9:38784439-38788327 (+)



Homology
more
  • Human Ortholog
    BSX, brain specific homeobox
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BSX, brain specific homeobox
  • Synonyms
    BSX1
  • Links
    NCBI Gene ID: 390259
    neXtProt AC: NX_Q3C1V8
    UniProt: Q3C1V8

  • Chr Location
    11q24.1; chr11:122977570-122981834 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 4 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for mutations in Bsx display increased fat mass, decreased food intake after fasting, decreased body temperature, and reduced locomotor activity, but body weight and glucose homoeostasis are similar to wild-type.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    30
  • cDNA Data
    7
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054360 Ensembl Gene Model | MGI Sequence Detail 5931 C57BL/6J ±  kb
    transcript ENSMUST00000067375 Ensembl | MGI Sequence Detail 2960 Not Applicable  
    polypeptide ENSMUSP00000068057 Ensembl | MGI Sequence Detail 232 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Other 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 11
      Gene Ontology 9
      Phenotypes 7
    • Earliest
      J:87378 Cremona M, et al., Bsx, an evolutionary conserved Brain Specific homeoboX gene expressed in the septum, epiphysis, mammillary bodies and arcuate nucleus. Gene Expr Patterns. 2004 Jan;4(1):47-51
    • Latest
      J:330767 Magno L, et al., Fate mapping reveals mixed embryonic origin and unique developmental codes of mouse forebrain septal neurons. Commun Biol. 2022 Oct 27;5(1):1137
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory