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Foxo6 Gene Detail
Summary
  • Symbol
    Foxo6
  • Name
    forkhead box O6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2676586
    NCBI Gene: 329934
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:120124275-120144458 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 56.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    372 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676586
 protein coding gene Chr4:120124275-120144546 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028707
 protein coding gene Chr4:121505248-121525533 (-)
A/J MGP_AJ_G0028667
 protein coding gene Chr4:116730192-116750468 (-)
AKR/J MGP_AKRJ_G0028620
 protein coding gene Chr4:119272177-119292448 (-)
BALB/cJ MGP_BALBcJ_G0028690
 protein coding gene Chr4:117347430-117367708 (-)
C3H/HeJ MGP_C3HHeJ_G0028405
 protein coding gene Chr4:120827530-120847808 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029131
 protein coding gene Chr4:126094071-126114341 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026408
 protein coding gene Chr4:110818542-110838793 (-)
CAST/EiJ MGP_CASTEiJ_G0027836
 protein coding gene Chr4:118175118-118195427 (-)
CBA/J MGP_CBAJ_G0028372
 protein coding gene Chr4:129510574-129530883 (-)
DBA/2J MGP_DBA2J_G0028519
 protein coding gene Chr4:117317470-117337987 (-)
FVB/NJ MGP_FVBNJ_G0028485
 protein coding gene Chr4:115838983-115860240 (-)
LP/J MGP_LPJ_G0028619
 protein coding gene Chr4:121640470-121662405 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028513
 protein coding gene Chr4:134371048-134391330 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029168
 protein coding gene Chr4:120349724-120369994 (-)
PWK/PhJ MGP_PWKPhJ_G0027559
 protein coding gene Chr4:114249695-114270070 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027385
 protein coding gene Chr4:116787023-116807517 (-)
WSB/EiJ MGP_WSBEiJ_G0027916
 protein coding gene Chr4:120359587-120380869 (-)



Homology
more
  • Human Ortholog
    FOXO6, forkhead box O6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXO6, forkhead box O6
  • Links
    NCBI Gene ID: 100132074
    UniProt: A8MYZ6

  • Chr Location
    1p34.2; chr1:41361434-41383590 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show defective memory consolidation with impaired neuronal synchronization and altered dendritic spine morphology. Homozygotes for another null allele show attenuated gluconeogenesis, improved glucose tolerance and increased insulin sensitivity after high fat feeding.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    42
  • cDNA Data
    8
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 329934 NCBI Gene Model | MGI Sequence Detail 20184 C57BL/6J ±  kb
    transcript NM_194060 RefSeq | MGI Sequence Detail 2528 C57BL/6  
    polypeptide Q70KY4 UniProt | EBI | MGI Sequence Detail 559 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 8
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory