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Mir26a-1 Gene Detail
Summary
  • Symbol
    Mir26a-1
  • Name
    microRNA 26a-1
  • Synonyms
    Mirn26a, Mirn26a-1, mmu-mir-26a-1
  • Feature Type
    miRNA gene
  • IDs
    MGI:2676900
    NCBI Gene: 387218
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr9:118860864-118860953 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 71.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676900
 miRNA gene Chr9:118860864-118860953 (+)
129S1/SvImJ MGP_129S1SvImJ_G0009248
 miRNA gene Chr9:121745760-121745849 (+)
A/J MGP_AJ_G0009228
 miRNA gene Chr9:117248840-117248929 (+)
AKR/J MGP_AKRJ_G0009218
 miRNA gene Chr9:120283206-120283295 (+)
BALB/cJ MGP_BALBcJ_G0009212
 miRNA gene Chr9:117113573-117113662 (+)
C3H/HeJ MGP_C3HHeJ_G0009152
 miRNA gene Chr9:120752450-120752539 (+)
C57BL/6NJ MGP_C57BL6NJ_G0009455
 miRNA gene Chr9:125087233-125087322 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0008304
 miRNA gene Chr9:114440951-114441040 (+)
CAST/EiJ MGP_CASTEiJ_G0008983
 miRNA gene Chr9:120707103-120707192 (+)
CBA/J MGP_CBAJ_G0009119
 miRNA gene Chr9:129789256-129789345 (+)
DBA/2J MGP_DBA2J_G0009149
 miRNA gene Chr9:116684245-116684334 (+)
FVB/NJ MGP_FVBNJ_G0009166
 miRNA gene Chr9:115524792-115524881 (+)
LP/J MGP_LPJ_G0009246
 miRNA gene Chr9:122090454-122090543 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0009133
 miRNA gene Chr9:130780417-130780506 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0009425
 miRNA gene Chr9:120669986-120670075 (+)
PWK/PhJ MGP_PWKPhJ_G0008908
 miRNA gene Chr9:117094816-117094905 (+)
SPRET/EiJ MGP_SPRETEiJ_G0008745
 miRNA gene Chr9:120762979-120763068 (+)
WSB/EiJ MGP_WSBEiJ_G0009077
 miRNA gene Chr9:120555957-120556046 (+)



Homology
more
  • Human Ortholog
    MIR26A1, microRNA 26a-1
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR26A1, microRNA 26a-1
  • Synonyms
    MIR26A, mir-26a-1, MIRN26A1
  • Links
    NCBI Gene ID: 407015

  • Chr Location
    chr3:37969404-37969480 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    18 phenotypes from multigenic genotypes
    2 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice double homozygous for Mir26a-1 and Mir26a-2 fed a high-fat diet exhibit beta cell hyperproliferation and hyperplasia with increased obesity, and insulin resistance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    22
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      24
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 387218 NCBI Gene Model | MGI Sequence Detail 90 C57BL/6J ±  kb
    transcript NR_029742 RefSeq | MGI Sequence Detail 90 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 5
      Primer pair 2
      Other 3
    Other Database
    Links
    less
    miRBase MI0000573
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 10
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:12215 Chubb C, Oligotriche and quaking gene mutations. Phenotypic effects on mouse spermatogenesis and testicular steroidogenesis. J Androl. 1992 Jul-Aug;13(4):312-7
    • Latest
      J:343881 Zeng H, et al., AP2-microRNA-26a overexpression reduces visceral fat mass and blood lipids. Mol Cell Endocrinol. 2021 May 15;528:111217
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory