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U2af1l4 Gene Detail
Summary
  • Symbol
    U2af1l4
  • Name
    U2 small nuclear RNA auxiliary factor 1-like 4
  • Synonyms
    auxiliary factor 26, U2af26
  • Feature Type
    protein coding gene
  • IDs
    MGI:2678374
    NCBI Gene: 233073
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30262765-30264789 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 18.61 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    130 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2678374
 protein coding gene Chr7:30262726-30264790 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032029
 protein coding gene Chr7:29571197-29575856 (+)
A/J MGP_AJ_G0032006
 protein coding gene Chr7:28768825-28773478 (+)
AKR/J MGP_AKRJ_G0031939
 protein coding gene Chr7:29499959-29504612 (+)
BALB/cJ MGP_BALBcJ_G0032013
 protein coding gene Chr7:28956259-28960912 (+)
C3H/HeJ MGP_C3HHeJ_G0031732
 protein coding gene Chr7:29958918-29963577 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032479
 protein coding gene Chr7:30520620-30525279 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029529
 protein coding gene Chr7:29795822-29800521 (+)
CAST/EiJ MGP_CASTEiJ_G0031066
 protein coding gene Chr7:23211666-23216321 (+)
CBA/J MGP_CBAJ_G0031698
 protein coding gene Chr7:31986595-31991254 (+)
DBA/2J MGP_DBA2J_G0031850
 protein coding gene Chr7:28497238-28501893 (+)
FVB/NJ MGP_FVBNJ_G0031807
 protein coding gene Chr7:28628109-28632768 (+)
LP/J MGP_LPJ_G0031931
 protein coding gene Chr7:29878239-29882933 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031843
 protein coding gene Chr7:31222395-31227056 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032507
 protein coding gene Chr7:29010846-29015519 (+)
PWK/PhJ MGP_PWKPhJ_G0030790
 protein coding gene Chr7:23532514-23539253 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030625
 protein coding gene Chr7:20018825-20023479 (+)
WSB/EiJ MGP_WSBEiJ_G0031176
 protein coding gene Chr7:29397977-29402621 (+)



Homology
more
  • Human Ortholog
    U2AF1L4, U2 small nuclear RNA auxiliary factor 1 like 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    U2AF1L4, U2 small nuclear RNA auxiliary factor 1 like 4
  • Synonyms
    U2AF1L3, U2AF1L3V1, U2AF1-RS3, U2AF1RS3, U2af26
  • Links
    NCBI Gene ID: 199746
    neXtProt AC: NX_Q8WU68
    UniProt: Q8WU68

  • Chr Location
    19q13.12; chr19:35742464-35745445 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display abnormal circadian rhythms in response to changing external cues.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    13
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 233073 NCBI Gene Model | MGI Sequence Detail 2025 C57BL/6J ±  kb
transcript NM_170760 RefSeq | MGI Sequence Detail 864 C57BL/6  
polypeptide Q8BGJ9 UniProt | EBI | MGI Sequence Detail 220 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141802, MGI:2141967, MGI:2142260
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:83847 Shepard J, et al., Characterization of U2AF(6), a splicing factor related to U2AF(35). Mol Cell Biol. 2002 Jan;22(1):221-30
  • Latest
    J:263646 Horiuchi K, et al., Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice. Cell Rep. 2018 Apr 3;23(1):143-155
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory