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Slitrk1 Gene Detail
Summary
  • Symbol
    Slitrk1
  • Name
    SLIT and NTRK-like family, member 1
  • Synonyms
    3200001I04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679446
    NCBI Gene: 76965
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:109147420-109151671 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 56.78 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    130 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2679446
 protein coding gene Chr14:109146232-109151671 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021641
 protein coding gene Chr14:105719954-105724202 (-)
A/J MGP_AJ_G0021599
 protein coding gene Chr14:102118124-102122372 (-)
AKR/J MGP_AKRJ_G0021575
 protein coding gene Chr14:105164431-105168679 (-)
BALB/cJ MGP_BALBcJ_G0021605
 protein coding gene Chr14:102548337-102552585 (-)
C3H/HeJ MGP_C3HHeJ_G0021383
 protein coding gene Chr14:105137578-105141826 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022045
 protein coding gene Chr14:109997395-110001643 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019585
 protein coding gene Chr14:98669495-98673734 (-)
CAST/EiJ MGP_CASTEiJ_G0020900
 protein coding gene Chr14:102630366-102634614 (-)
CBA/J MGP_CBAJ_G0021351
 protein coding gene Chr14:113931842-113936090 (-)
DBA/2J MGP_DBA2J_G0021475
 protein coding gene Chr14:101692146-101696394 (-)
FVB/NJ MGP_FVBNJ_G0021452
 protein coding gene Chr14:100515874-100520132 (-)
LP/J MGP_LPJ_G0021543
 protein coding gene Chr14:106599193-106603435 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021479
 protein coding gene Chr14:117587243-117591485 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022068
 protein coding gene Chr14:104745575-104749823 (-)
PWK/PhJ MGP_PWKPhJ_G0020643
 protein coding gene Chr14:98619737-98623984 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020481
 protein coding gene Chr14:100809319-100813569 (-)
WSB/EiJ MGP_WSBEiJ_G0020953
 protein coding gene Chr14:105392571-105396819 (-)



Homology
more
  • Human Ortholog
    SLITRK1, SLIT and NTRK like family member 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLITRK1, SLIT and NTRK like family member 1
  • Synonyms
    LRRC12, TTM
  • Links
    NCBI Gene ID: 114798
    neXtProt AC: NX_Q96PX8
    UniProt: Q96PX8

  • Chr Location
    13q31.1; chr13:83877205-83882474 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slitrk1 mouse models; 2 with human SLITRK1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display hypoactivity, reduced male body weight, elevated anxiety- and depression-like behavior, increased norepinephrine content in brain, and partial postnatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1061
  • Tissues
    132
  • cDNA Data
    34
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76965 NCBI Gene Model | MGI Sequence Detail 4252 C57BL/6J ±  kb
    transcript NM_199065 RefSeq | MGI Sequence Detail 4266 C57BL/6  
    polypeptide Q810C1 UniProt | EBI | MGI Sequence Detail 696 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 34
      Primer pair 4
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1924215
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 11
      Phenotypes 16
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:348363 Matsumoto Y, et al., Slitrk4 is required for the development of inhibitory neurons in the fear memory circuit of the lateral amygdala. Front Mol Neurosci. 2024;17:1386924
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory