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Hapln4 Gene Detail
Summary
  • Symbol
    Hapln4
  • Name
    hyaluronan and proteoglycan link protein 4
  • Synonyms
    Bral2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679531
    NCBI Gene: 330790
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:70536179-70543512 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    227 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2679531
 protein coding gene Chr8:70536107-70543512 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033688
 protein coding gene Chr8:70332488-70339793 (+)
A/J MGP_AJ_G0033671
 protein coding gene Chr8:67469904-67477237 (+)
AKR/J MGP_AKRJ_G0033596
 protein coding gene Chr8:69390381-69397679 (+)
BALB/cJ MGP_BALBcJ_G0033667
 protein coding gene Chr8:67700248-67707549 (+)
C3H/HeJ MGP_C3HHeJ_G0033377
 protein coding gene Chr8:70035988-70043285 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034184
 protein coding gene Chr8:72988961-72996294 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031128
 protein coding gene Chr8:62289008-62296292 (+)
CAST/EiJ MGP_CASTEiJ_G0032702
 protein coding gene Chr8:69517226-69524580 (+)
CBA/J MGP_CBAJ_G0033355
 protein coding gene Chr8:75632235-75639532 (+)
DBA/2J MGP_DBA2J_G0033509
 protein coding gene Chr8:67196939-67204236 (+)
FVB/NJ MGP_FVBNJ_G0033450
 protein coding gene Chr8:66295356-66302653 (+)
LP/J MGP_LPJ_G0033596
 protein coding gene Chr8:70372193-70379494 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033494
 protein coding gene Chr8:78294370-78301699 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034202
 protein coding gene Chr8:69570838-69578137 (+)
PWK/PhJ MGP_PWKPhJ_G0032410
 protein coding gene Chr8:66481619-66488950 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032246
 protein coding gene Chr8:68544578-68551987 (+)
WSB/EiJ MGP_WSBEiJ_G0032817
 protein coding gene Chr8:69931865-69939178 (+)



Homology
more
  • Human Ortholog
    HAPLN4, hyaluronan and proteoglycan link protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HAPLN4, hyaluronan and proteoglycan link protein 4
  • Synonyms
    BRAL2
  • Links
    NCBI Gene ID: 404037
    neXtProt AC: NX_Q86UW8
    UniProt: Q86UW8

  • Chr Location
    19p13.11; chr19:19254756-19262804 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit attenuated perineuronal nets and synapses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    46
  • cDNA Data
    13
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 330790 NCBI Gene Model | MGI Sequence Detail 7334 C57BL/6J ±  kb
transcript NM_177900 RefSeq | MGI Sequence Detail 3576 C57BL/6  
polypeptide Q80WM4 UniProt | EBI | MGI Sequence Detail 400 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 4
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 16
  • Earliest
    J:83776 Spicer AP, et al., A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links. J Biol Chem. 2003 Jun 6;278(23):21083-91
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory