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Zfp335 Gene Detail
Summary
  • Symbol
    Zfp335
  • Name
    zinc finger protein 335
  • Synonyms
    1810045J01Rik, MGC:86001
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682313
    NCBI Gene: 329559
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164733802-164753677 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    505 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2682313
 protein coding gene Chr2:164733802-164756034 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026882
 protein coding gene Chr2:170404906-170424798 (-)
A/J MGP_AJ_G0026849
 protein coding gene Chr2:163430387-163450287 (-)
AKR/J MGP_AKRJ_G0026820
 protein coding gene Chr2:168310069-168330207 (-)
BALB/cJ MGP_BALBcJ_G0026858
 protein coding gene Chr2:163797438-163817583 (-)
C3H/HeJ MGP_C3HHeJ_G0026600
 protein coding gene Chr2:168657574-168678437 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027305
 protein coding gene Chr2:175344256-175364140 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024676
 protein coding gene Chr2:156837862-156859165 (-)
CAST/EiJ MGP_CASTEiJ_G0026058
 protein coding gene Chr2:169071488-169091552 (-)
CBA/J MGP_CBAJ_G0026577
 protein coding gene Chr2:181708996-181729190 (-)
DBA/2J MGP_DBA2J_G0026715
 protein coding gene Chr2:162597173-162617468 (-)
FVB/NJ MGP_FVBNJ_G0026681
 protein coding gene Chr2:161019011-161040108 (-)
LP/J MGP_LPJ_G0026817
 protein coding gene Chr2:170459576-170481263 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026700
 protein coding gene Chr2:185250528-185271767 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027362
 protein coding gene Chr2:168194224-168218881 (-)
PWK/PhJ MGP_PWKPhJ_G0025795
 protein coding gene Chr2:162200481-162220607 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025596
 protein coding gene Chr2:167099711-167119584 (-)
WSB/EiJ MGP_WSBEiJ_G0026131
 protein coding gene Chr2:169076730-169099245 (-)



Homology
more
  • Human Ortholog
    ZNF335, zinc finger protein 335
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNF335, zinc finger protein 335
  • Synonyms
    MCPH10, NIF-1, NIF1, NIF2
  • Links
    NCBI Gene ID: 63925
    neXtProt AC: NX_Q9H4Z2
    UniProt: Q9H4Z2

  • Chr Location
    20q13.12; chr20:45948660-45972203 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ZNF335 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 5 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality before implantation. Mice homozygous for a conditional allele activated in the brain exhibit loss of cortical neurons and decreased brain size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    15
  • cDNA Data
    43
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039834 Ensembl Gene Model | MGI Sequence Detail 19876 C57BL/6J ±  kb
    transcript ENSMUST00000041361 Ensembl | MGI Sequence Detail 4587 Not Applicable  
    polypeptide ENSMUSP00000038298 Ensembl | MGI Sequence Detail 1337 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 45

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917051
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:334079 Ratiu JJ, et al., Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-beta selection thymocytes. Nat Commun. 2022 Oct 6;13(1):5901
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory