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Smg7 Gene Detail
Summary
  • Symbol
    Smg7
  • Name
    SMG7 nonsense mediated mRNA decay factor
  • Synonyms
    9430023P16Rik, mKIAA0250, Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682334
    NCBI Gene: 226517
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:152712746-152778397 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 65.07 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1344 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2682334
 protein coding gene Chr1:152712746-152783212 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016592
 protein coding gene Chr1:157616778-157684107 (-)
A/J MGP_AJ_G0016574
 protein coding gene Chr1:151264025-151330422 (-)
AKR/J MGP_AKRJ_G0016539
 protein coding gene Chr1:155940292-156011808 (-)
BALB/cJ MGP_BALBcJ_G0016534
 protein coding gene Chr1:151838079-151904339 (-)
C3H/HeJ MGP_C3HHeJ_G0016359
 protein coding gene Chr1:156043112-156111032 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016995
 protein coding gene Chr1:163061978-163133268 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014704
 protein coding gene Chr1:143582305-143646143 (-)
CAST/EiJ MGP_CASTEiJ_G0015938
 protein coding gene Chr1:155547118-155617505 (-)
CBA/J MGP_CBAJ_G0016333
 protein coding gene Chr1:168804795-168877042 (-)
DBA/2J MGP_DBA2J_G0016439
 protein coding gene Chr1:150278968-150345428 (-)
FVB/NJ MGP_FVBNJ_G0016437
 protein coding gene Chr1:148767627-148833138 (-)
LP/J MGP_LPJ_G0016510
 protein coding gene Chr1:158728971-158800594 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016463
 protein coding gene Chr1:176448211-176519893 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017031
 protein coding gene Chr1:155717959-155786087 (-)
PWK/PhJ MGP_PWKPhJ_G0015724
 protein coding gene Chr1:149296144-149362971 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015511
 protein coding gene Chr1:154523293-154595547 (-)
WSB/EiJ MGP_WSBEiJ_G0016001
 protein coding gene Chr1:155781343-155852081 (-)



Homology
more
  • Human Ortholog
    SMG7, SMG7 nonsense mediated mRNA decay factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMG7, SMG7 nonsense mediated mRNA decay factor
  • Synonyms
    C1orf16, EST1C, SGA56M
  • Links
    NCBI Gene ID: 9887
    neXtProt AC: NX_Q92540
    UniProt: Q92540

  • Chr Location
    1q25.3; chr1:183472216-183598246 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    105
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042772 Ensembl Gene Model | MGI Sequence Detail 65652 C57BL/6J ±  kb
transcript ENSMUST00000043560 Ensembl | MGI Sequence Detail 5792 Not Applicable  
polypeptide ENSMUSP00000041241 Ensembl | MGI Sequence Detail 1146 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015286 nonsense-mediated mRNA decay factor SMG7
    (term hierarchy)
  • InterPro Domains
    IPR018834 DNA/RNA-binding domain, Est1-type
    IPR045153 Est1/Ebs1-like
    IPR019458 Telomerase activating protein Est1-like, N-terminal
    IPR011990 Tetratricopeptide-like helical domain superfamily
  • GlyGen
    Q5RJH6 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)
Molecular
Reagents
less
  • All nucleic 106
    cDNA 106

    Microarray probesets 1
References
more
  • Summaries
    All 33
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:336915 Steiner AJ, et al., Characterization of a rhabdomyosarcoma reveals a critical role for SMG7 in cancer cell viability and tumor growth. Sci Rep. 2023 Jun 22;13(1):10152
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory