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Zhx2 Gene Detail
Summary
  • Symbol
    Zhx2
  • Name
    zinc fingers and homeoboxes 2
  • Synonyms
    Afr-1, Afr1, mKIAA0854, Raf
  • Feature Type
    protein coding gene
  • IDs
    MGI:2683087
    NCBI Gene: 387609
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:57558063-57703228 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 24.01 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3989 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2683087
 protein coding gene Chr15:57558061-57703228 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021861
 protein coding gene Chr15:56831064-56988681 (+)
A/J MGP_AJ_G0021821
 protein coding gene Chr15:54601930-54750809 (+)
AKR/J MGP_AKRJ_G0021802
 protein coding gene Chr15:56095047-56241303 (+)
BALB/cJ MGP_BALBcJ_G0021828
 protein coding gene Chr15:54829028-54977446 (+)
C3H/HeJ MGP_C3HHeJ_G0021602
 protein coding gene Chr15:56235599-56393744 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022267
 protein coding gene Chr15:59054044-59208992 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019804
 protein coding gene Chr15:51704166-51846104 (+)
CAST/EiJ MGP_CASTEiJ_G0021119
 protein coding gene Chr15:56847045-57013211 (+)
CBA/J MGP_CBAJ_G0021571
 protein coding gene Chr15:61101635-61272632 (+)
DBA/2J MGP_DBA2J_G0021695
 protein coding gene Chr15:54529668-54676754 (+)
FVB/NJ MGP_FVBNJ_G0021673
 protein coding gene Chr15:53580119-53726348 (+)
LP/J MGP_LPJ_G0021765
 protein coding gene Chr15:56678490-56834691 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021697
 protein coding gene Chr15:66200999-66357448 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022290
 protein coding gene Chr15:56523189-56683174 (+)
PWK/PhJ MGP_PWKPhJ_G0020864
 protein coding gene Chr15:54526313-54661729 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020701
 protein coding gene Chr15:56299965-56433814 (+)
WSB/EiJ MGP_WSBEiJ_G0021174
 protein coding gene Chr15:56497487-56657118 (+)



Homology
more
  • Human Ortholog
    ZHX2, zinc fingers and homeoboxes 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZHX2, zinc fingers and homeoboxes 2
  • Synonyms
    AFR1, RAF
  • Links
    NCBI Gene ID: 22882
    neXtProt AC: NX_Q9Y6X8
    UniProt: Q9Y6X8

  • Chr Location
    8q24.13; chr8:122780379-122974510 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Alpha-fetoprotein levels in plasma decline precipitously after birth. This gene regulates a difference in adult level and rate of neonatal decrease of AFP. The BALB/cJ substrain carries a genetic variant allele determining a slow rate of decline to adultlevel.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    30
  • cDNA Data
    35
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 387609 NCBI Gene Model | MGI Sequence Detail 145166 C57BL/6J ±  kb
    transcript NM_199449 RefSeq | MGI Sequence Detail 4392 ZRU/MplStud  
    polypeptide Q8C0C0 UniProt | EBI | MGI Sequence Detail 836 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 35
      Primer pair 1
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-1174, MGD-MRK-1176, MGD-MRK-13750, MGI:87952
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 14
      Phenotypes 28
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:342959 Zhang Y, et al., ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury. Nat Commun. 2023 Nov 18;14(1):7527
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory