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Ifnk Gene Detail
Summary
  • Symbol
    Ifnk
  • Name
    interferon kappa
  • Feature Type
    protein coding gene
  • IDs
    MGI:2683287
    NCBI Gene: 387510
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr4:35152056-35154005 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 17.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    172 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2683287
 protein coding gene Chr4:35152055-35154019 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028136
 protein coding gene Chr4:32772047-32773996 (+)
A/J MGP_AJ_G0028094
 protein coding gene Chr4:31575860-31577731 (+)
AKR/J MGP_AKRJ_G0028057
 protein coding gene Chr4:32414038-32415909 (+)
BALB/cJ MGP_BALBcJ_G0028106
 protein coding gene Chr4:31852491-31854440 (+)
C3H/HeJ MGP_C3HHeJ_G0027834
 protein coding gene Chr4:32737179-32739050 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028547
 protein coding gene Chr4:34024322-34026271 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025888
 protein coding gene Chr4:29659754-29661966 (+)
CAST/EiJ MGP_CASTEiJ_G0027290
 protein coding gene Chr4:32529944-32531822 (+)
CBA/J MGP_CBAJ_G0027806
 protein coding gene Chr4:35139962-35141833 (+)
DBA/2J MGP_DBA2J_G0027950
 protein coding gene Chr4:31542099-31543970 (+)
FVB/NJ MGP_FVBNJ_G0027917
 protein coding gene Chr4:30961954-30963825 (+)
LP/J MGP_LPJ_G0028058
 protein coding gene Chr4:32878780-32880729 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027950
 protein coding gene Chr4:37750070-37751941 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028606
 protein coding gene Chr4:32436056-32438005 (+)
PWK/PhJ MGP_PWKPhJ_G0027008
 protein coding gene Chr4:31581614-31583610 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026837
 protein coding gene Chr4:32305088-32307062 (+)
WSB/EiJ MGP_WSBEiJ_G0027366
 protein coding gene Chr4:32433922-32435793 (+)



Homology
more
  • Human Ortholog
    IFNK, interferon kappa
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFNK, interferon kappa
  • Synonyms
    IFNT1, INFE1
  • Links
    NCBI Gene ID: 56832
    neXtProt AC: NX_Q9P0W0
    UniProt: Q9P0W0

  • Chr Location
    chr9:27524290-27526498 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit resistance to IMQ-induced psoriasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    14
  • cDNA Data
    3
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042993 Ensembl Gene Model | MGI Sequence Detail 1950 C57BL/6J ±  kb
    transcript ENSMUST00000058595 Ensembl | MGI Sequence Detail 805 Not Applicable  
    polypeptide ENSMUSP00000054273 Ensembl | MGI Sequence Detail 199 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 1
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:83469 Vassileva G, et al., Expression of a novel murine type I IFN in the pancreatic islets induces diabetes in mice. J Immunol. 2003 Jun 1;170(11):5748-55
    • Latest
      J:349239 Loftus SN, et al., Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1. Front Immunol. 2024;15:1384606
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory