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Rere Gene Detail
Summary
  • Symbol
    Rere
  • Name
    arginine glutamic acid dipeptide (RE) repeats
  • Synonyms
    1110033A15Rik, Atr2, atrophin-2, eye03, eyem03Jus, eyes3, mKIAA0458
  • Feature Type
    protein coding gene
  • IDs
    MGI:2683486
    NCBI Gene: 68703
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:150366103-150706423 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 81.34 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2220 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2683486
 protein coding gene Chr4:150365372-150706423 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029154
 protein coding gene Chr4:154235896-154604846 (+)
A/J MGP_AJ_G0029119
 protein coding gene Chr4:147767105-148114816 (+)
AKR/J MGP_AKRJ_G0029067
 protein coding gene Chr4:151821422-152174728 (+)
BALB/cJ MGP_BALBcJ_G0029135
 protein coding gene Chr4:148264202-148610990 (+)
C3H/HeJ MGP_C3HHeJ_G0028856
 protein coding gene Chr4:152364390-152723413 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029584
 protein coding gene Chr4:159788993-160160959 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026830
 protein coding gene Chr4:140176037-140518409 (+)
CAST/EiJ MGP_CASTEiJ_G0028269
 protein coding gene Chr4:149635456-150000996 (+)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0028967
 protein coding gene Chr4:147857329-148199248 (+)
FVB/NJ MGP_FVBNJ_G0028931
 protein coding gene Chr4:146989855-147339310 (+)
LP/J MGP_LPJ_G0029057
 protein coding gene Chr4:154165713-154541644 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028958
 protein coding gene Chr4:167639766-168016190 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029616
 protein coding gene Chr4:152331150-152691204 (+)
PWK/PhJ MGP_PWKPhJ_G0027989
 protein coding gene Chr4:143883659-144230332 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027823
 protein coding gene Chr4:146591004-146954113 (+)
WSB/EiJ MGP_WSBEiJ_G0028349
 protein coding gene Chr4:152470359-152829980 (+)



Homology
more
  • Human Ortholog
    RERE, arginine-glutamic acid dipeptide repeats
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RERE, arginine-glutamic acid dipeptide repeats
  • Synonyms
    ARG, ARP, ATN1L, DNB1, NEDBEH
  • Links
    NCBI Gene ID: 473
    neXtProt AC: NX_Q9P2R6
    UniProt: Q9P2R6

  • Chr Location
    1p36.23; chr1:8352397-8848921 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 4 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    6 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display embryonic lethality with abnormalities in neural tube development, somite development, and in the embryonic heart. Mice homozygous for an ENU-induced allele exhibit narrow snouts, decreased body weight, renal agenesis and small eyes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    907
  • Tissues
    84
  • cDNA Data
    185
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039852 Ensembl Gene Model | MGI Sequence Detail 340321 C57BL/6J ±  kb
    transcript ENSMUST00000105682 Ensembl | MGI Sequence Detail 7728 Not Applicable  
    polypeptide ENSMUSP00000101307 Ensembl | MGI Sequence Detail 1558 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 185
      cDNA 185

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915953, MGI:2140258, MGI:2140608, MGI:3577417
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 11
      Gene Ontology 9
      Phenotypes 24
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:326544 Alam SS, et al., Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis. Dis Model Mech. 2022 Jun 1;15(6):dmm049544
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory