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Lrsam1 Gene Detail
Summary
  • Symbol
    Lrsam1
  • Name
    leucine rich repeat and sterile alpha motif containing 1
  • Synonyms
    MGC:56830
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684789
    NCBI Gene: 227738
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:32815228-32851626 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.09 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1230 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684789
 protein coding gene Chr2:32815227-32851666 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025627
 protein coding gene Chr2:31427629-31463768 (-)
A/J MGP_AJ_G0025604
 protein coding gene Chr2:30082761-30119706 (-)
AKR/J MGP_AKRJ_G0025574
 protein coding gene Chr2:31161794-31199319 (-)
BALB/cJ MGP_BALBcJ_G0025601
 protein coding gene Chr2:30202924-30240011 (-)
C3H/HeJ MGP_C3HHeJ_G0025361
 protein coding gene Chr2:31046281-31082899 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026045
 protein coding gene Chr2:32371605-32411614 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023454
 protein coding gene Chr2:28809246-28847486 (-)
CAST/EiJ MGP_CASTEiJ_G0024823
 protein coding gene Chr2:31005363-31045299 (-)
CBA/J MGP_CBAJ_G0025339
 protein coding gene Chr2:33611845-33654393 (-)
DBA/2J MGP_DBA2J_G0025472
 protein coding gene Chr2:29847532-29884261 (-)
FVB/NJ MGP_FVBNJ_G0025434
 protein coding gene Chr2:29735486-29772359 (-)
LP/J MGP_LPJ_G0025558
 protein coding gene Chr2:31307169-31347894 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025465
 protein coding gene Chr2:33211788-33249268 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026103
 protein coding gene Chr2:31036291-31073266 (-)
PWK/PhJ MGP_PWKPhJ_G0024571
 protein coding gene Chr2:29758417-29797836 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024371
 protein coding gene Chr2:31190902-31232465 (-)
WSB/EiJ MGP_WSBEiJ_G0024892
 protein coding gene Chr2:31222932-31261983 (-)



Homology
more
  • Human Ortholog
    LRSAM1, leucine rich repeat and sterile alpha motif containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRSAM1, leucine rich repeat and sterile alpha motif containing 1
  • Synonyms
    CMT2P, RIFLE, TAL
  • Links
    NCBI Gene ID: 90678
    neXtProt AC: NX_Q6UWE0
    UniProt: Q6UWE0

  • Chr Location
    9q33.3-q34.11; chr9:127451486-127503501 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lrsam1 mouse models; 1 with human LRSAM1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant mice either heterozygous or homozygous for a gene trapped allele exhibit mild neuromuscular junction and axonal defects in the absence of a neuronal challenge, but show increased sensitivity to acrylamide-induced motor axon degeneration relative to control mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    753
  • Tissues
    8
  • cDNA Data
    43
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026792 Ensembl Gene Model | MGI Sequence Detail 36399 C57BL/6J ±  kb
    transcript ENSMUST00000113200 Ensembl | MGI Sequence Detail 4030 Not Applicable  
    polypeptide ENSMUSP00000108825 Ensembl | MGI Sequence Detail 727 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 43

      Microarray probesets 2
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory