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Lclat1 Gene Detail
Summary
  • Symbol
    Lclat1
  • Name
    lysocardiolipin acyltransferase 1
  • Synonyms
    AGPAT8, ALCAT1, Lycat
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684937
    NCBI Gene: 225010
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:73414980-73550363 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 44.79 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4025 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684937
 protein coding gene Chr17:73414980-73550363 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024018
 protein coding gene Chr17:75665394-75799443 (+)
A/J MGP_AJ_G0023976
 protein coding gene Chr17:73353507-73486874 (+)
AKR/J MGP_AKRJ_G0023945
 protein coding gene Chr17:74389013-74524816 (+)
BALB/cJ MGP_BALBcJ_G0023977
 protein coding gene Chr17:73270243-73405640 (+)
C3H/HeJ MGP_C3HHeJ_G0023741
 protein coding gene Chr17:75317254-75453305 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024423
 protein coding gene Chr17:78393877-78533143 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021867
 protein coding gene Chr17:69058967-69179880 (+)
CAST/EiJ MGP_CASTEiJ_G0023222
 protein coding gene Chr17:75766777-75903379 (+)
CBA/J MGP_CBAJ_G0023716
 protein coding gene Chr17:81630826-81776141 (+)
DBA/2J MGP_DBA2J_G0023845
 protein coding gene Chr17:71985491-72115944 (+)
FVB/NJ MGP_FVBNJ_G0023811
 protein coding gene Chr17:71453708-71586458 (+)
LP/J MGP_LPJ_G0023927
 protein coding gene Chr17:76398882-76534425 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023839
 protein coding gene Chr17:81477354-81612516 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024467
 protein coding gene Chr17:74890165-75024392 (+)
PWK/PhJ MGP_PWKPhJ_G0022968
 protein coding gene Chr17:71321454-71451938 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022779
 protein coding gene Chr17:71555004-71691228 (+)
WSB/EiJ MGP_WSBEiJ_G0023289
 protein coding gene Chr17:75739342-75873618 (+)



Homology
more
  • Human Ortholog
    LCLAT1, lysocardiolipin acyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LCLAT1, lysocardiolipin acyltransferase 1
  • Synonyms
    1AGPAT8, AGPAT8, ALCAT1, HSRG1849, LPLAT6, LYCAT, UNQ1849
  • Links
    NCBI Gene ID: 253558
    neXtProt AC: NX_Q6UWP7
    UniProt: Q6UWP7

  • Chr Location
    2p23.1; chr2:30447226-30644225 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a knock-out allele and fed a high fat diet exhibit resistance to diet induced obesity, decreased total body fat, increased insulin sensitivity, polyphagia, hyperactivity, increased energy expenditure, and increased fatty acid oxidation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    843
  • Tissues
    132
  • cDNA Data
    65
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 225010 NCBI Gene Model | MGI Sequence Detail 135384 C57BL/6J ±  kb
    transcript NM_001081071 RefSeq | MGI Sequence Detail 4476 C57BL/6  
    polypeptide Q3UN02 UniProt | EBI | MGI Sequence Detail 376 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 65
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146804
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345721 Zhang J, et al., An upstream open reading frame (5'-uORF) links oxidative stress to translational control of ALCAT1 through phosphorylation of eIF2alpha. Free Radic Biol Med. 2024 Mar;214:129-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory