About   Help   FAQ
Wfdc6a Gene Detail
Summary
  • Symbol
    Wfdc6a
  • Name
    WAP four-disulfide core domain 6A
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684968
    NCBI Gene: 209351
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164421439-164427367 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    326 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684968
 protein coding gene Chr2:164421439-164427704 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0026825
 protein coding gene Chr2:163111764-163118141 (-)
AKR/J MGP_AKRJ_G0026799
 protein coding gene Chr2:167997293-168003076 (+)
BALB/cJ MGP_BALBcJ_G0026837
 protein coding gene Chr2:163508135-163513192 (+)
C3H/HeJ MGP_C3HHeJ_G0026579
 protein coding gene Chr2:168352097-168361799 (+)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0024654
 protein coding gene Chr2:156540850-156561550 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0026553
 protein coding gene Chr2:181312338-181318587 (-)
DBA/2J MGP_DBA2J_G0026691
 protein coding gene Chr2:162280784-162286556 (-)
FVB/NJ MGP_FVBNJ_G0026657
 protein coding gene Chr2:160701287-160706979 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0026677
 protein coding gene Chr2:184890522-184902018 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027338
 protein coding gene Chr2:167863798-167871182 (-)
PWK/PhJ MGP_PWKPhJ_G0025770
 protein coding gene Chr2:161828824-161832744 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0026110
 protein coding gene Chr2:168775396-168785635 (+)



Homology
more
  • Human Ortholog
    EPPIN, epididymal peptidase inhibitor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPPIN, epididymal peptidase inhibitor
  • Synonyms
    CT71, CT72, dJ461P17.2, SPINLW1, WAP7, WFDC7
  • Links
    NCBI Gene ID: 57119
    neXtProt AC: NX_O95925
    UniProt: O95925

  • Chr Location
    20q13.12; chr20:45540626-45547752 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074595 Ensembl Gene Model | MGI Sequence Detail 5929 C57BL/6J ±  kb
transcript ENSMUST00000099096 Ensembl | MGI Sequence Detail 805 Not Applicable  
polypeptide ENSMUSP00000096694 Ensembl | MGI Sequence Detail 136 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000033432 WAP four-disulfide core domain protein 6A
    (term hierarchy)
  • InterPro Domains
    IPR036645 Elafin-like superfamily
    IPR002223 Pancreatic trypsin inhibitor Kunitz domain
    IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
    IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
    IPR051388 Serine protease inhibitor and venom toxin
    IPR008197 WAP-type 'four-disulfide core' domain
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:300068 Andrade AD, et al., Lipopolysaccharide-induced epididymitis modifies the transcriptional profile of Wfdc genes in mice. Biol Reprod. 2021 Jan 4;104(1):144-158
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory