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Pex10 Gene Detail
Summary
  • Symbol
    Pex10
  • Name
    peroxisomal biogenesis factor 10
  • Synonyms
    LOC230983, peroxisome biogenesis factor 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684988
    NCBI Gene: 668173
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:155151487-155156863 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 86.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    240 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684988
 protein coding gene Chr4:155151473-155156890 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029206
 protein coding gene Chr4:159355289-159360706 (+)
A/J MGP_AJ_G0029171
 protein coding gene Chr4:152675055-152680472 (+)
AKR/J MGP_AKRJ_G0029119
 protein coding gene Chr4:156830385-156835802 (+)
BALB/cJ MGP_BALBcJ_G0029187
 protein coding gene Chr4:153147855-153153272 (+)
C3H/HeJ MGP_C3HHeJ_G0028908
 protein coding gene Chr4:157365130-157370547 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029636
 protein coding gene Chr4:165053046-165058463 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026882
 protein coding gene Chr4:144972917-144978346 (+)
CAST/EiJ MGP_CASTEiJ_G0028321
 protein coding gene Chr4:154796231-154801636 (+)
CBA/J MGP_CBAJ_G0028870
 protein coding gene Chr4:169991331-169996748 (+)
DBA/2J MGP_DBA2J_G0029019
 protein coding gene Chr4:152695012-152700429 (+)
FVB/NJ MGP_FVBNJ_G0028983
 protein coding gene Chr4:151925503-151930920 (+)
LP/J MGP_LPJ_G0029109
 protein coding gene Chr4:159281758-159287175 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029010
 protein coding gene Chr4:172866414-172871831 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029668
 protein coding gene Chr4:157430942-157436359 (+)
PWK/PhJ MGP_PWKPhJ_G0028041
 protein coding gene Chr4:148819228-148824738 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027875
 protein coding gene Chr4:151707097-151712535 (+)
WSB/EiJ MGP_WSBEiJ_G0028401
 protein coding gene Chr4:157591149-157596566 (+)



Homology
more
  • Human Ortholog
    PEX10, peroxisomal biogenesis factor 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PEX10, peroxisomal biogenesis factor 10
  • Synonyms
    NALD, PBD6A, PBD6B, RNF69
  • Links
    NCBI Gene ID: 5192
    neXtProt AC: NX_O60683
    UniProt: O60683

  • Chr Location
    1p36.32; chr1:2403964-2413827 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PEX10 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit partial neonatal mortality due to respiratory distress, loss of embryonic movement, and prenatal pathology including altered biochemistry, defects in axonal integrity, decreased Schwann cell number, and defects at the neuromuscular junction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    5
  • cDNA Data
    25
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 668173 NCBI Gene Model | MGI Sequence Detail 5377 C57BL/6J ±  kb
    transcript NM_001042407 RefSeq | MGI Sequence Detail 1647 C57BL/6  
    polypeptide B1AUE5 UniProt | EBI | MGI Sequence Detail 324 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 26

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:3034175
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:216140 Hanson MG, et al., Peripheral nervous system defects in a mouse model for peroxisomal biogenesis disorders. Dev Biol. 2014 Nov 1;395(1):84-95
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory