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Hmcn1 Gene Detail
Summary
  • Symbol
    Hmcn1
  • Name
    hemicentin 1
  • Synonyms
    EG545370, LOC240793
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685047
    NCBI Gene: 545370
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:150438275-150869186 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 63.84 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13237 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685047
 protein coding gene Chr1:150438251-150869568 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016578
 protein coding gene Chr1:155214924-155661316 (-)
A/J MGP_AJ_G0016560
 protein coding gene Chr1:148963554-149396304 (-)
AKR/J MGP_AKRJ_G0016525
 protein coding gene Chr1:153514657-153958002 (-)
BALB/cJ MGP_BALBcJ_G0016520
 protein coding gene Chr1:149491655-149929410 (-)
C3H/HeJ MGP_C3HHeJ_G0016345
 protein coding gene Chr1:153692900-154142277 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016981
 protein coding gene Chr1:160595561-161072786 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014690
 protein coding gene Chr1:141321909-141749354 (-)
CAST/EiJ MGP_CASTEiJ_G0015924
 protein coding gene Chr1:153088140-153548965 (-)
CBA/J MGP_CBAJ_G0016319
 protein coding gene Chr1:166263537-166745868 (-)
DBA/2J MGP_DBA2J_G0016425
 protein coding gene Chr1:148016352-148454903 (-)
FVB/NJ MGP_FVBNJ_G0016423
 protein coding gene Chr1:146472074-146908095 (-)
LP/J MGP_LPJ_G0016496
 protein coding gene Chr1:156242727-156699053 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016449
 protein coding gene Chr1:173954186-174440628 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017017
 protein coding gene Chr1:153328806-153768426 (-)
PWK/PhJ MGP_PWKPhJ_G0015710
 protein coding gene Chr1:146940248-147388039 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015497
 protein coding gene Chr1:152128027-152589910 (-)
WSB/EiJ MGP_WSBEiJ_G0015987
 protein coding gene Chr1:153407611-153863191 (-)



Homology
more
  • Human Ortholog
    HMCN1, hemicentin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMCN1, hemicentin 1
  • Synonyms
    ARMD1, FBLN6, FIBL-6, FIBL6
  • Links
    NCBI Gene ID: 83872
    neXtProt AC: NX_Q96RW7
    UniProt: Q96RW7

  • Chr Location
    1q25.3-q31.1; chr1:185734391-186190949 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HMCN1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 4 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele are viable and fertile with no gross abnormalities. Mice homozygous for a second null allele display hyperactivity and cataracts.Mice homozygous for a third null allele display failure of zygotic cell division.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    39
  • cDNA Data
    29
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000066842 Ensembl Gene Model | MGI Sequence Detail 430912 C57BL/6J ±  kb
    transcript ENSMUST00000074783 Ensembl | MGI Sequence Detail 17908 Not Applicable  
    polypeptide ENSMUSP00000074340 Ensembl | MGI Sequence Detail 5634 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008624 hemicentin-1
      (term hierarchy)
    • InterPro Domains
      IPR050958 Cell Adhesion and Cytoskeletal Organization
      IPR026823 Complement Clr-like EGF domain
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR006605 G2 nidogen/fibulin G2F
      IPR009017 Green fluorescent protein
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR013098 Immunoglobulin I-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003599 Immunoglobulin subtype
      IPR003598 Immunoglobulin subtype 2
      IPR013106 Immunoglobulin V-set domain
      IPR052235 Nephronectin domain-containing protein
      IPR049883 NOTCH1 EGF-like calcium-binding domain
      IPR000884 Thrombospondin type-1 (TSP1) repeat
      IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
      IPR052577 von Willebrand factor A domain-containing protein 7
      IPR036465 von Willebrand factor A-like domain superfamily
    • GlyGen
      D3YXG0 22 sites, 10 N-linked glycans (12 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 29
      Primer pair 2
      Other 1

      Microarray probesets 78
    Other
    Accession IDs
    less
    MGI:3646881
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 6
      Gene Ontology 13
      Phenotypes 14
    • Earliest
      J:123065 Xu X, et al., Hemicentins assemble on diverse epithelia in the mouse. J Histochem Cytochem. 2007 Feb;55(2):119-26
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory