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Slc30a10 Gene Detail
Summary
  • Symbol
    Slc30a10
  • Name
    solute carrier family 30, member 10
  • Synonyms
    E130106K10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685058
    NCBI Gene: 226781
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:185187045-185200959 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 89.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    505 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685058
 protein coding gene Chr1:185187045-185200959 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016917
 protein coding gene Chr1:192193985-192207829 (+)
A/J MGP_AJ_G0016896
 protein coding gene Chr1:184332045-184345911 (+)
AKR/J MGP_AKRJ_G0016861
 protein coding gene Chr1:189766042-189779888 (+)
BALB/cJ MGP_BALBcJ_G0016854
 protein coding gene Chr1:184974098-184987976 (+)
C3H/HeJ MGP_C3HHeJ_G0016678
 protein coding gene Chr1:190634100-190647973 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017317
 protein coding gene Chr1:198325977-198339860 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015024
 protein coding gene Chr1:175320033-175332684 (+)
CAST/EiJ MGP_CASTEiJ_G0016261
 protein coding gene Chr1:190065261-190079048 (+)
CBA/J MGP_CBAJ_G0016652
 protein coding gene Chr1:205723159-205736957 (+)
DBA/2J MGP_DBA2J_G0016758
 protein coding gene Chr1:183090534-183104154 (+)
FVB/NJ MGP_FVBNJ_G0016754
 protein coding gene Chr1:181191489-181205360 (+)
LP/J MGP_LPJ_G0016833
 protein coding gene Chr1:193343150-193356996 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016786
 protein coding gene Chr1:212594276-212608159 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017354
 protein coding gene Chr1:189638172-189652074 (+)
PWK/PhJ MGP_PWKPhJ_G0016048
 protein coding gene Chr1:182302970-182316927 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015824
 protein coding gene Chr1:188593109-188606712 (+)
WSB/EiJ MGP_WSBEiJ_G0016323
 protein coding gene Chr1:189802153-189815772 (+)



Homology
more
  • Human Ortholog
    SLC30A10, solute carrier family 30 member 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC30A10, solute carrier family 30 member 10
  • Synonyms
    HMDPC, HMNDYT1, ZnT-10, ZNT10, ZNT8, ZRC1
  • Links
    NCBI Gene ID: 55532
    neXtProt AC: NX_Q6XR72
    UniProt: Q6XR72

  • Chr Location
    1q41; chr1:219685427-219959098 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLC30A10 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit post-weaning growth defects, increased manganese levels in the brain, blood, liver and thyroid gland, severe hypothyroidism and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    29
  • cDNA Data
    25
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 226781 NCBI Gene Model | MGI Sequence Detail 13915 C57BL/6J ±  kb
    transcript NM_001033286 RefSeq | MGI Sequence Detail 5836 C57BL/6  
    polypeptide Q3UVU3 UniProt | EBI | MGI Sequence Detail 470 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 1
      cDNA 25
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory