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Gpr174 Gene Detail
Summary
  • Symbol
    Gpr174
  • Name
    G protein-coupled receptor 174
  • Synonyms
    LOC213439
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685222
    NCBI Gene: 213439
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:106299484-106340375 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 47.48 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    763 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685222
 protein coding gene ChrX:106299484-106340377 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036013
 protein coding gene ChrX:104089775-104132442 (+)
A/J MGP_AJ_G0035992
 protein coding gene ChrX:103922924-103965017 (+)
AKR/J MGP_AKRJ_G0035911
 protein coding gene ChrX:107189646-107232277 (+)
BALB/cJ MGP_BALBcJ_G0035983
 protein coding gene ChrX:102675335-102718164 (+)
C3H/HeJ MGP_C3HHeJ_G0035689
 protein coding gene ChrX:104556090-104603937 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036509
 protein coding gene ChrX:107103079-107147901 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033337
 protein coding gene ChrX:101222906-101255400 (+)
CAST/EiJ MGP_CASTEiJ_G0034976
 protein coding gene ChrX:88650522-88689977 (+)
CBA/J MGP_CBAJ_G0035665
 protein coding gene ChrX:110438159-110481697 (+)
DBA/2J MGP_DBA2J_G0035819
 protein coding gene ChrX:103152336-103191967 (+)
FVB/NJ MGP_FVBNJ_G0035759
 protein coding gene ChrX:102491713-102532333 (+)
LP/J MGP_LPJ_G0035911
 protein coding gene ChrX:105037059-105084916 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035790
 protein coding gene ChrX:115214038-115269784 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036536
 protein coding gene ChrX:103665480-103706814 (+)
PWK/PhJ MGP_PWKPhJ_G0034672
 protein coding gene ChrX:86193953-86234274 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034501
 protein coding gene ChrX:89448844-89489299 (+)
WSB/EiJ MGP_WSBEiJ_G0035114
 protein coding gene ChrX:102409198-102453516 (+)



Homology
more
  • Human Ortholog
    GPR174, G protein-coupled receptor 174
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR174, G protein-coupled receptor 174
  • Synonyms
    FKSG79, GPCR17, LPS3, LYPSR3
  • Links
    NCBI Gene ID: 84636
    neXtProt AC: NX_Q9BXC1
    UniProt: Q9BXC1

  • Chr Location
    Xq21.1; chrX:79144688-79175318 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous for a knock-out allele exhibit abnormal T cell proliferation, abnormal regulatory T cell physiology and decreased susceptibility to EAE.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    15
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000073008 Ensembl Gene Model | MGI Sequence Detail 40892 C57BL/6J ±  kb
transcript ENSMUST00000117310 Ensembl | MGI Sequence Detail 3536 Not Applicable  
polypeptide ENSMUSP00000112808 Ensembl | MGI Sequence Detail 335 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 4
References
more
  • Summaries
    All 31
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:332042 Liu J, et al., GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression. Nat Commun. 2022 Dec 6;13(1):7519
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory