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Hdx Gene Detail
Summary
  • Symbol
    Hdx
  • Name
    highly divergent homeobox
  • Synonyms
    D030011N01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685226
    NCBI Gene: 245596
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:110484901-110606908 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 48.29 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1864 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685226
 protein coding gene ChrX:110479628-110606908 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036028
 protein coding gene ChrX:108302382-108404257 (-)
A/J MGP_AJ_G0036008
 protein coding gene ChrX:108184513-108289081 (-)
AKR/J MGP_AKRJ_G0035927
 protein coding gene ChrX:111530516-111642615 (-)
BALB/cJ MGP_BALBcJ_G0036000
 protein coding gene ChrX:106824633-106927153 (-)
C3H/HeJ MGP_C3HHeJ_G0035705
 protein coding gene ChrX:108756866-108860329 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036524
 protein coding gene ChrX:111479846-111580714 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033351
 protein coding gene ChrX:104974629-105099954 (-)
CAST/EiJ MGP_CASTEiJ_G0034991
 protein coding gene ChrX:92682205-92787128 (-)
CBA/J MGP_CBAJ_G0035681
 protein coding gene ChrX:114984289-115124279 (-)
DBA/2J MGP_DBA2J_G0035834
 protein coding gene ChrX:107323963-107426942 (-)
FVB/NJ MGP_FVBNJ_G0035775
 protein coding gene ChrX:106710782-106806881 (-)
LP/J MGP_LPJ_G0035927
 protein coding gene ChrX:109194822-109299401 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035806
 protein coding gene ChrX:120328636-120487265 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036551
 protein coding gene ChrX:107867130-107966611 (-)
PWK/PhJ MGP_PWKPhJ_G0034686
 protein coding gene ChrX:90194930-90295958 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034517
 protein coding gene ChrX:93544090-93651568 (-)
WSB/EiJ MGP_WSBEiJ_G0035129
 protein coding gene ChrX:106668681-106776383 (-)



Homology
more
  • Human Ortholog
    HDX, highly divergent homeobox
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HDX, highly divergent homeobox
  • Synonyms
    CXorf43, D030011N01Rik
  • Links
    NCBI Gene ID: 139324
    neXtProt AC: NX_Q7Z353
    UniProt: Q7Z353

  • Chr Location
    Xq21.1; chrX:84317874-84502479 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 images
    8 phenotype references
Male chimeras hemizygous for a gene trapped allele appear normal at E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    23
  • cDNA Data
    11
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 245596 NCBI Gene Model | MGI Sequence Detail 122008 C57BL/6J ±  kb
transcript NM_001080549 RefSeq | MGI Sequence Detail 4261 C57BL/6  
polypeptide Q14B70 UniProt | EBI | MGI Sequence Detail 692 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 2
References
more
  • Summaries
    All 30
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory