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Col28a1 Gene Detail
Summary
  • Symbol
    Col28a1
  • Name
    collagen, type XXVIII, alpha 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685312
    NCBI Gene: 213945
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:7997808-8192617 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 3.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    6592 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685312
 protein coding gene Chr6:7997100-8193709 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030446
 protein coding gene Chr6:4880666-5067180 (-)
A/J MGP_AJ_G0030419
 protein coding gene Chr6:4746729-4926853 (-)
AKR/J MGP_AKRJ_G0030346
 protein coding gene Chr6:4910393-5097244 (-)
BALB/cJ MGP_BALBcJ_G0030428
 protein coding gene Chr6:4715071-4908769 (-)
C3H/HeJ MGP_C3HHeJ_G0030142
 protein coding gene Chr6:4806124-5004631 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030883
 protein coding gene Chr6:5051467-5256761 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028094
 protein coding gene Chr6:4268748-4451362 (-)
CAST/EiJ MGP_CASTEiJ_G0029543
 protein coding gene Chr6:4785331-4993456 (-)
CBA/J MGP_CBAJ_G0030120
 protein coding gene Chr6:5185178-5401507 (-)
DBA/2J MGP_DBA2J_G0030264
 protein coding gene Chr6:4681731-4855822 (-)
FVB/NJ MGP_FVBNJ_G0030218
 protein coding gene Chr6:4666876-4833827 (-)
LP/J MGP_LPJ_G0030351
 protein coding gene Chr6:4873017-5078365 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030254
 protein coding gene Chr6:5272453-5480483 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030913
 protein coding gene Chr6:4815592-4992576 (-)
PWK/PhJ MGP_PWKPhJ_G0029258
 protein coding gene Chr6:4563187-4746474 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029094
 protein coding gene Chr6:4849235-5032973 (-)
WSB/EiJ MGP_WSBEiJ_G0029620
 protein coding gene Chr6:4780692-4976636 (-)



Homology
more
  • Human Ortholog
    COL28A1, collagen type XXVIII alpha 1 chain
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COL28A1, collagen type XXVIII alpha 1 chain
  • Synonyms
    COL28
  • Links
    NCBI Gene ID: 340267
    neXtProt AC: NX_Q2UY09
    UniProt: Q2UY09

  • Chr Location
    7p21.3; chr7:7338194-7543870 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    25
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068794 Ensembl Gene Model | MGI Sequence Detail 194810 C57BL/6J ±  kb
    transcript ENSMUST00000115537 Ensembl | MGI Sequence Detail 4230 Not Applicable  
    polypeptide ENSMUSP00000111199 Ensembl | MGI Sequence Detail 1141 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005711 collagen alpha-1(XXVIII) chain
      (term hierarchy)
    • InterPro Domains
      IPR050149 Collagen superfamily
      IPR050525 Extracellular Matrix Assembly and Organization
      IPR002223 Pancreatic trypsin inhibitor Kunitz domain
      IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
      IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
      IPR036465 von Willebrand factor A-like domain superfamily
      IPR002035 von Willebrand factor, type A
    Molecular
    Reagents
    less
    • All nucleic 2
      Primer pair 1
      Other 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 21
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:108496 Veit G, et al., Collagen XXVIII, a novel von Willebrand factor A domain-containing protein with many imperfections in the collagenous domain. J Biol Chem. 2006 Feb 10;281(6):3494-504
    • Latest
      J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory