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Asap2 Gene Detail
Summary
  • Symbol
    Asap2
  • Name
    ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
  • Synonyms
    6530401G17Rik, Ddef2, LOC385250
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685438
    NCBI Gene: 211914
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:21161369-21320172 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 8.29 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4285 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685438
 protein coding gene Chr12:21040460-21320172 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019621
 protein coding gene Chr12:18718109-18820014 (+)
A/J MGP_AJ_G0019588
 protein coding gene Chr12:18014374-18113655 (+)
AKR/J MGP_AKRJ_G0019559
 protein coding gene Chr12:18840633-18947448 (+)
BALB/cJ MGP_BALBcJ_G0019565
 protein coding gene Chr12:18391940-18488448 (+)
C3H/HeJ MGP_C3HHeJ_G0019369
 protein coding gene Chr12:18733078-18838883 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020013
 protein coding gene Chr12:19408583-19516323 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017638
 protein coding gene Chr12:17613815-17712723 (+)
CAST/EiJ MGP_CASTEiJ_G0018924
 protein coding gene Chr12:15898488-16113423 (+)
CBA/J MGP_CBAJ_G0019341
 protein coding gene Chr12:20140282-20252814 (+)
DBA/2J MGP_DBA2J_G0019454
 protein coding gene Chr12:18046023-18146369 (+)
FVB/NJ MGP_FVBNJ_G0019445
 protein coding gene Chr12:17947061-18047945 (+)
LP/J MGP_LPJ_G0019524
 protein coding gene Chr12:18816841-18921254 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019480
 protein coding gene Chr12:19971283-20075712 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020052
 protein coding gene Chr12:18421793-18523319 (+)
PWK/PhJ MGP_PWKPhJ_G0018690
 protein coding gene Chr12:15313546-15415831 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018479
 protein coding gene Chr12:15708743-15810406 (+)
WSB/EiJ MGP_WSBEiJ_G0018975
 protein coding gene Chr12:18602208-18707635 (+)



Homology
more
  • Human Ortholog
    ASAP2, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASAP2, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
  • Synonyms
    AMAP2, CENTB3, DDEF2, PAG3, PAP, Pap-alpha, SHAG1
  • Links
    NCBI Gene ID: 8853
    neXtProt AC: NX_O43150
    UniProt: O43150

  • Chr Location
    2p25; chr2:9206765-9405683 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    12
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 211914 NCBI Gene Model | MGI Sequence Detail 158804 C57BL/6J ±  kb
transcript NM_001135192 RefSeq | MGI Sequence Detail 5686 C57BL/6  
polypeptide Q7SIG6 UniProt | EBI | MGI Sequence Detail 958 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 2
Other
Accession IDs
less
MGI:1923478, MGI:2686369
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory