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Wdtc1 Gene Detail
Summary
  • Symbol
    Wdtc1
  • Name
    WD and tetratricopeptide repeats 1
  • Synonyms
    adipose, adp, LOC230796
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685541
    NCBI Gene: 230796
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:133019770-133080792 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 66.25 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1684 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685541
 protein coding gene Chr4:133019770-133080811 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028892
 protein coding gene Chr4:135530630-135592315 (-)
A/J MGP_AJ_G0028851
 protein coding gene Chr4:129862988-129925315 (-)
AKR/J MGP_AKRJ_G0028804
 protein coding gene Chr4:133548064-133615513 (-)
BALB/cJ MGP_BALBcJ_G0028874
 protein coding gene Chr4:130483135-130548144 (-)
C3H/HeJ MGP_C3HHeJ_G0028588
 protein coding gene Chr4:133797204-133860349 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029316
 protein coding gene Chr4:140403356-140472081 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026587
 protein coding gene Chr4:122942972-123003054 (-)
CAST/EiJ MGP_CASTEiJ_G0028021
 protein coding gene Chr4:131908093-131975189 (-)
CBA/J MGP_CBAJ_G0028554
 protein coding gene Chr4:144056771-144131780 (-)
DBA/2J MGP_DBA2J_G0028703
 protein coding gene Chr4:130282952-130344960 (-)
FVB/NJ MGP_FVBNJ_G0028670
 protein coding gene Chr4:129157420-129221424 (-)
LP/J MGP_LPJ_G0028804
 protein coding gene Chr4:135660166-135722937 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028696
 protein coding gene Chr4:148584287-148658837 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029354
 protein coding gene Chr4:133965056-134026985 (-)
PWK/PhJ MGP_PWKPhJ_G0027742
 protein coding gene Chr4:126985740-127058921 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027568
 protein coding gene Chr4:129808157-129874796 (-)
WSB/EiJ MGP_WSBEiJ_G0028101
 protein coding gene Chr4:134140285-134207343 (-)



Homology
more
  • Human Ortholog
    WDTC1, WD and tetratricopeptide repeats 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDTC1, WD and tetratricopeptide repeats 1
  • Synonyms
    ADP, DCAF9
  • Links
    NCBI Gene ID: 23038
    neXtProt AC: NX_Q8N5D0
    UniProt: Q8N5D0

  • Chr Location
    1p36.11; chr1:27234441-27308636 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 4 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a gene trapped allele are obese and insulin resistant with significantly elevated plasma insulin and leptin levels. Although a number of adult homozygotes are also described as obese, the majority of homozygotes die in utero thus precluding statistically significant analyses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    7
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037622 Ensembl Gene Model | MGI Sequence Detail 61023 C57BL/6J ±  kb
    transcript ENSMUST00000043305 Ensembl | MGI Sequence Detail 4191 Not Applicable  
    polypeptide ENSMUSP00000040647 Ensembl | MGI Sequence Detail 677 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000031217 WD and tetratricopeptide repeats protein 1
      (term hierarchy)
    • InterPro Domains
      IPR045151 DDB1- and CUL4-associated factor 8-like
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q80ZK9 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 2
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 17
    • Earliest
      J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory