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Arhgef33 Gene Detail
Summary
  • Symbol
    Arhgef33
  • Name
    Rho guanine nucleotide exchange factor 33
  • Synonyms
    Gm941, LOC381112
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685787
    NCBI Gene: 381112
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:80614836-80707510 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 50.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2785 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685787
 protein coding gene Chr17:80614354-80740926 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024062
 protein coding gene Chr17:83221976-83307567 (+)
A/J MGP_AJ_G0024019
 protein coding gene Chr17:80678915-80762841 (+)
AKR/J MGP_AKRJ_G0023988
 protein coding gene Chr17:81935908-82024347 (+)
BALB/cJ MGP_BALBcJ_G0024021
 protein coding gene Chr17:80546796-80628669 (+)
C3H/HeJ MGP_C3HHeJ_G0023785
 protein coding gene Chr17:82803298-82888566 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024465
 protein coding gene Chr17:86256376-86343755 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021906
 protein coding gene Chr17:76032216-76108845 (+)
CAST/EiJ MGP_CASTEiJ_G0023265
 protein coding gene Chr17:83482077-83569677 (+)
CBA/J MGP_CBAJ_G0023759
 protein coding gene Chr17:89852647-89958878 (+)
DBA/2J MGP_DBA2J_G0023888
 protein coding gene Chr17:79171446-79252748 (+)
FVB/NJ MGP_FVBNJ_G0023854
 protein coding gene Chr17:78671369-78753338 (+)
LP/J MGP_LPJ_G0023971
 protein coding gene Chr17:84059420-84142842 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023882
 protein coding gene Chr17:89895318-89984882 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024510
 protein coding gene Chr17:82414233-82502295 (+)
PWK/PhJ MGP_PWKPhJ_G0023011
 protein coding gene Chr17:78713253-78797792 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022822
 protein coding gene Chr17:79186344-79272343 (+)
WSB/EiJ MGP_WSBEiJ_G0023332
 protein coding gene Chr17:83232664-83321173 (+)



Homology
more
  • Human Ortholog
    ARHGEF33, Rho guanine nucleotide exchange factor 33
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGEF33, Rho guanine nucleotide exchange factor 33
  • Links
    NCBI Gene ID: 100271715
    neXtProt AC: NX_A8MVX0
    UniProt: A8MVX0

  • Chr Location
    chr2:38889875-38975454 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054901 Ensembl Gene Model | MGI Sequence Detail 92675 C57BL/6J ±  kb
transcript ENSMUST00000068175 Ensembl | MGI Sequence Detail 3260 Not Applicable  
polypeptide ENSMUSP00000063284 Ensembl | MGI Sequence Detail 850 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 20
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 4
  • Earliest
    J:240526 Hall EA, et al., PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins. Am J Hum Genet. 2017 May 4;100(5):706-724
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory