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Cracr2a Gene Detail
Summary
  • Symbol
    Cracr2a
  • Name
    calcium release activated channel regulator 2A
  • Synonyms
    Efcab4b, LOC243645, LOC381812
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685919
    NCBI Gene: 381812
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:127538299-127651197 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 62.39 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3206 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685919
 protein coding gene Chr6:127538299-127651211 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031315
 protein coding gene Chr6:131086093-131161185 (+)
A/J MGP_AJ_G0031286
 protein coding gene Chr6:126082783-126151846 (+)
AKR/J MGP_AKRJ_G0031214
 protein coding gene Chr6:129487331-129556976 (+)
BALB/cJ MGP_BALBcJ_G0031293
 protein coding gene Chr6:125639608-125709428 (+)
C3H/HeJ MGP_C3HHeJ_G0031017
 protein coding gene Chr6:129626117-129698000 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031750
 protein coding gene Chr6:134506290-134587065 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028898
 protein coding gene Chr6:123256449-123325909 (+)
CAST/EiJ MGP_CASTEiJ_G0030398
 protein coding gene Chr6:129847172-129921161 (+)
CBA/J MGP_CBAJ_G0030978
 protein coding gene Chr6:139667420-139756729 (+)
DBA/2J MGP_DBA2J_G0031134
 protein coding gene Chr6:124970953-125039897 (+)
FVB/NJ MGP_FVBNJ_G0031083
 protein coding gene Chr6:123893232-123961886 (+)
LP/J MGP_LPJ_G0031214
 protein coding gene Chr6:131178420-131253491 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031122
 protein coding gene Chr6:143598785-143670854 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031785
 protein coding gene Chr6:129460869-129533211 (+)
PWK/PhJ MGP_PWKPhJ_G0030113
 protein coding gene Chr6:123249591-123322016 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029942
 protein coding gene Chr6:127550230-127631638 (+)
WSB/EiJ MGP_WSBEiJ_G0030483
 protein coding gene Chr6:129825432-129904593 (+)



Homology
more
  • Human Ortholog
    CRACR2A, calcium release activated channel regulator 2A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRACR2A, calcium release activated channel regulator 2A
  • Synonyms
    EFCAB4B, RAB46
  • Links
    NCBI Gene ID: 84766
    neXtProt AC: NX_Q9BSW2
    UniProt: Q9BSW2

  • Chr Location
    12p13.32; chr12:3606633-3764819 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    15
  • cDNA Data
    3
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 381812 NCBI Gene Model | MGI Sequence Detail 112899 C57BL/6J ±  kb
transcript NM_001368877 RefSeq | MGI Sequence Detail 7613 C57BL/6  
polypeptide Q3UP38 UniProt | EBI | MGI Sequence Detail 726 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 1
Other
Accession IDs
less
MGI:2685308
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 10
    Phenotypes 6
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory