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Pglyrp4 Gene Detail
Summary
  • Symbol
    Pglyrp4
  • Name
    peptidoglycan recognition protein 4
  • Synonyms
    LOC242097, LOC384997, PglyrpIb
  • Feature Type
    protein coding gene
  • IDs
    MGI:2686324
    NCBI Gene: 384997
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:90634213-90648824 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.96 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    323 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2686324
 protein coding gene Chr3:90634008-90648824 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027481
 protein coding gene Chr3:91069977-91083797 (+)
A/J MGP_AJ_G0027445
 protein coding gene Chr3:88025753-88041504 (+)
AKR/J MGP_AKRJ_G0027410
 protein coding gene Chr3:90195165-90209837 (+)
BALB/cJ MGP_BALBcJ_G0027454
 protein coding gene Chr3:87981922-87996495 (+)
C3H/HeJ MGP_C3HHeJ_G0027196
 protein coding gene Chr3:90353356-90368790 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027900
 protein coding gene Chr3:94468375-94485071 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025253
 protein coding gene Chr3:83520971-83535098 (+)
CAST/EiJ MGP_CASTEiJ_G0026642
 protein coding gene Chr3:90756038-90775745 (+)
CBA/J MGP_CBAJ_G0027171
 protein coding gene Chr3:97668686-97682992 (+)
DBA/2J MGP_DBA2J_G0027308
 protein coding gene Chr3:87391887-87406662 (+)
FVB/NJ MGP_FVBNJ_G0027276
 protein coding gene Chr3:85719613-85735106 (+)
LP/J MGP_LPJ_G0027417
 protein coding gene Chr3:92125346-92142278 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027297
 protein coding gene Chr3:103927708-103949861 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027959
 protein coding gene Chr3:89943354-89968358 (+)
PWK/PhJ MGP_PWKPhJ_G0026376
 protein coding gene Chr3:87291057-87306011 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026196
 protein coding gene Chr3:89127830-89141636 (+)
WSB/EiJ MGP_WSBEiJ_G0026724
 protein coding gene Chr3:90349808-90365630 (+)



Homology
more
  • Human Ortholog
    PGLYRP4, peptidoglycan recognition protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGLYRP4, peptidoglycan recognition protein 4
  • Synonyms
    PGLYRPIbeta, PGRPIB, PGRP-Ibeta, SBBI67
  • Links
    NCBI Gene ID: 57115
    neXtProt AC: NX_Q96LB8
    UniProt: Q96LB8

  • Chr Location
    1q21.3; chr1:153330120-153348841 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to DSS-induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    22
  • cDNA Data
    2
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042250 Ensembl Gene Model | MGI Sequence Detail 14612 C57BL/6J ±  kb
    transcript ENSMUST00000169698 Ensembl | MGI Sequence Detail 2229 Not Applicable  
    polypeptide ENSMUSP00000128113 Ensembl | MGI Sequence Detail 375 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000012613 peptidoglycan recognition protein 4
      (term hierarchy)
    • InterPro Domains
      IPR002502 N-acetylmuramoyl-L-alanine amidase domain
      IPR036505 N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily
      IPR015510 Peptidoglycan recognition protein
      IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria
    • GlyGen
      Q0VB07 3 sites
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 2
      Primer pair 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2685259
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory