About   Help   FAQ
Scn4b Gene Detail
Summary
  • Symbol
    Scn4b
  • Name
    sodium channel, type IV, beta
  • Synonyms
    LOC384934
  • Feature Type
    protein coding gene
  • IDs
    MGI:2687406
    NCBI Gene: 399548
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:45049922-45065453 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    385 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2687406
 protein coding gene Chr9:45049693-45065453 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034732
 protein coding gene Chr9:43684498-43700245 (+)
A/J MGP_AJ_G0034713
 protein coding gene Chr9:42464740-42480538 (+)
AKR/J MGP_AKRJ_G0034640
 protein coding gene Chr9:43338877-43354585 (+)
BALB/cJ MGP_BALBcJ_G0034704
 protein coding gene Chr9:42198133-42213839 (+)
C3H/HeJ MGP_C3HHeJ_G0034415
 protein coding gene Chr9:43795703-43811426 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035225
 protein coding gene Chr9:44961164-44979063 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032139
 protein coding gene Chr9:42018602-42034861 (+)
CAST/EiJ MGP_CASTEiJ_G0033737
 protein coding gene Chr9:43655091-43671398 (+)
CBA/J MGP_CBAJ_G0034387
 protein coding gene Chr9:46611432-46630091 (+)
DBA/2J MGP_DBA2J_G0034546
 protein coding gene Chr9:42353004-42370119 (+)
FVB/NJ MGP_FVBNJ_G0034487
 protein coding gene Chr9:41610290-41625995 (+)
LP/J MGP_LPJ_G0034627
 protein coding gene Chr9:43981727-43997480 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034531
 protein coding gene Chr9:48432921-48448633 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035246
 protein coding gene Chr9:43258994-43274712 (+)
PWK/PhJ MGP_PWKPhJ_G0033442
 protein coding gene Chr9:42240524-42256434 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033278
 protein coding gene Chr9:43550663-43566467 (+)
WSB/EiJ MGP_WSBEiJ_G0033850
 protein coding gene Chr9:43288463-43304184 (+)



Homology
more
  • Human Ortholog
    SCN4B, sodium voltage-gated channel beta subunit 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCN4B, sodium voltage-gated channel beta subunit 4
  • Synonyms
    ATFB17, LQT10, Navbeta4
  • Links
    NCBI Gene ID: 6330
    neXtProt AC: NX_Q8IWT1
    UniProt: Q8IWT1

  • Chr Location
    11q23.3; chr11:118133377-118152888 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SCN4B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit depolarizing shifts in action potential thresholds in core accumbens medium spiny neurons, and reduced ability to induce spike-timing-dependent long-term depression (tLTD). Amphetamine-induced locomotor activity is reduced in male mutant mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    7
  • cDNA Data
    9
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 399548 NCBI Gene Model | MGI Sequence Detail 15532 C57BL/6J ±  kb
transcript NM_001013390 RefSeq | MGI Sequence Detail 4771 C57BL/6  
polypeptide Q7M729 UniProt | EBI | MGI Sequence Detail 228 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    Genomic 2
    cDNA 9
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2686317
References
more
  • Summaries
    All 41
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:98459 Grieco TM, et al., Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current. Neuron. 2005 Jan 20;45(2):233-44
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory