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Pde11a Gene Detail
Summary
  • Symbol
    Pde11a
  • Name
    phosphodiesterase 11A
  • Synonyms
    6330414F14Rik, A630086N24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036251
    NCBI Gene: 241489
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:75819485-76169118 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 44.80 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10284 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3036251
 protein coding gene Chr2:75816152-76169501 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025862
 protein coding gene Chr2:76378811-76734188 (-)
A/J MGP_AJ_G0025839
 protein coding gene Chr2:73390640-73747808 (-)
AKR/J MGP_AKRJ_G0025808
 protein coding gene Chr2:75370349-75726670 (-)
BALB/cJ MGP_BALBcJ_G0025834
 protein coding gene Chr2:73572947-73927628 (-)
C3H/HeJ MGP_C3HHeJ_G0025594
 protein coding gene Chr2:75581069-75938899 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026281
 protein coding gene Chr2:78643652-79005766 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023683
 protein coding gene Chr2:70803683-71154627 (-)
CAST/EiJ MGP_CASTEiJ_G0025056
 protein coding gene Chr2:75899234-76272133 (-)
CBA/J MGP_CBAJ_G0025575
 protein coding gene Chr2:81544130-81931603 (-)
DBA/2J MGP_DBA2J_G0025706
 protein coding gene Chr2:72982058-73331790 (-)
FVB/NJ MGP_FVBNJ_G0025668
 protein coding gene Chr2:72365024-72710384 (-)
LP/J MGP_LPJ_G0025794
 protein coding gene Chr2:76247982-76613051 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025699
 protein coding gene Chr2:83404118-83769077 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026337
 protein coding gene Chr2:75505562-75855589 (-)
PWK/PhJ MGP_PWKPhJ_G0024799
 protein coding gene Chr2:72945564-73296467 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024605
 protein coding gene Chr2:75731335-76093485 (-)
WSB/EiJ MGP_WSBEiJ_G0025125
 protein coding gene Chr2:75959774-76315643 (-)



Homology
more
  • Human Ortholog
    PDE11A, phosphodiesterase 11A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE11A, phosphodiesterase 11A
  • Synonyms
    PPNAD2
  • Links
    NCBI Gene ID: 50940
    neXtProt AC: NX_Q9HCR9
    UniProt: Q9HCR9

  • Chr Location
    2q31.2; chr2:177623244-178108339 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PDE11A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele have enlarged lateral ventricles and exhibit abnormal behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1001
  • Tissues
    235
  • cDNA Data
    4
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000075270 Ensembl Gene Model | MGI Sequence Detail 349634 C57BL/6J ±  kb
    transcript ENSMUST00000099992 Ensembl | MGI Sequence Detail 4189 Not Applicable  
    polypeptide ENSMUSP00000097572 Ensembl | MGI Sequence Detail 933 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 2
      cDNA 5
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1923982
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 22
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory