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Duox2 Gene Detail
Summary
  • Symbol
    Duox2
  • Name
    dual oxidase 2
  • Synonyms
    A430065P05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3036280
    NCBI Gene: 214593
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:122109728-122128930 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 60.61 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    539 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3036280
 protein coding gene Chr2:122109727-122129221 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026410
 protein coding gene Chr2:125276487-125299951 (-)
A/J MGP_AJ_G0026372
 protein coding gene Chr2:120149860-120174334 (-)
AKR/J MGP_AKRJ_G0026349
 protein coding gene Chr2:123520565-123540753 (-)
BALB/cJ MGP_BALBcJ_G0026384
 protein coding gene Chr2:120383081-120404025 (-)
C3H/HeJ MGP_C3HHeJ_G0026129
 protein coding gene Chr2:124004584-124023178 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026831
 protein coding gene Chr2:129346440-129366142 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024210
 protein coding gene Chr2:115125836-115144260 (-)
CAST/EiJ MGP_CASTEiJ_G0025591
 protein coding gene Chr2:124341967-124364331 (-)
CBA/J MGP_CBAJ_G0026108
 protein coding gene Chr2:133885337-133916571 (-)
DBA/2J MGP_DBA2J_G0026245
 protein coding gene Chr2:119551984-119570585 (-)
FVB/NJ MGP_FVBNJ_G0026207
 protein coding gene Chr2:118347123-118350004 (-)
LP/J MGP_LPJ_G0026347
 protein coding gene Chr2:125526552-125545216 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026227
 protein coding gene Chr2:138105276-138127160 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026886
 protein coding gene Chr2:123639096-123657985 (-)
PWK/PhJ MGP_PWKPhJ_G0025327
 protein coding gene Chr2:119164122-119184336 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025127
 protein coding gene Chr2:122780617-122801221 (-)
WSB/EiJ MGP_WSBEiJ_G0025663
 protein coding gene Chr2:124495485-124519059 (-)



Homology
more
  • Human Ortholog
    DUOX2, dual oxidase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DUOX2, dual oxidase 2
  • Synonyms
    LNOX2, NOXEF2, P138-TOX, TDH6, THOX2
  • Links
    NCBI Gene ID: 50506
    neXtProt AC: NX_Q9NRD8
    UniProt: Q9NRD8

  • Chr Location
    15q21.1; chr15:45092650-45114172 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Duox2 mouse models; 2 with human DUOX2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 4 alleles in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous mutation fail to breed and are congenitally hypothyroid (low T4, high TSH), dwarf, and hearing impaired. Anterior pituitaries are dysplastic. Cochlear defects include delayed formation of the inner sulcus and tunnel of Corti and a thickened tectorial membrane.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    825
  • Tissues
    99
  • cDNA Data
    5
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068452 Ensembl Gene Model | MGI Sequence Detail 19203 C57BL/6J ±  kb
    transcript ENSMUST00000237546 Ensembl | MGI Sequence Detail 6112 Not Applicable  
    polypeptide ENSMUSP00000158204 Ensembl | MGI Sequence Detail 1545 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • EC
      1.6.3.1
    • InterPro Domains
      IPR034821 Dual oxidase, peroxidase domain
      IPR018247 EF-Hand 1, calcium-binding site
      IPR002048 EF-hand domain
      IPR011992 EF-hand domain pair
      IPR013112 FAD-binding 8
      IPR017927 FAD-binding domain, ferredoxin reductase-type
      IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
      IPR013121 Ferric reductase, NAD binding domain
      IPR013130 Ferric reductase transmembrane component-like domain
      IPR019791 Haem peroxidase, animal-type
      IPR037120 Haem peroxidase domain superfamily, animal type
      IPR010255 Haem peroxidase superfamily
      IPR050369 Respiratory burst oxidase/Ferric reductase
      IPR017938 Riboflavin synthase-like beta-barrel
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 5
      Primer pair 3

      Microarray probesets 1
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 3
      Phenotypes 16
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory