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Tox3 Gene Detail
Summary
  • Symbol
    Tox3
  • Name
    TOX high mobility group box family member 3
  • Synonyms
    500-9, C230068E13, CAGF9, Tnrc9
  • Feature Type
    protein coding gene
  • IDs
    MGI:3039593
    NCBI Gene: 244579
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:90973668-91074971 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 43.96 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2524 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3039593
 protein coding gene Chr8:90973665-91075746 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033926
 protein coding gene Chr8:91422445-91525123 (-)
A/J MGP_AJ_G0033909
 protein coding gene Chr8:87831491-87936769 (-)
AKR/J MGP_AKRJ_G0033835
 protein coding gene Chr8:90325335-90426173 (-)
BALB/cJ MGP_BALBcJ_G0033901
 protein coding gene Chr8:87974970-88075703 (-)
C3H/HeJ MGP_C3HHeJ_G0033611
 protein coding gene Chr8:90990926-91096814 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034422
 protein coding gene Chr8:94840684-94943991 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031363
 protein coding gene Chr8:81796974-81896571 (-)
CAST/EiJ MGP_CASTEiJ_G0032943
 protein coding gene Chr8:90482039-90589498 (-)
CBA/J MGP_CBAJ_G0033587
 protein coding gene Chr8:98034934-98140129 (-)
DBA/2J MGP_DBA2J_G0033741
 protein coding gene Chr8:87395212-87494990 (-)
FVB/NJ MGP_FVBNJ_G0033688
 protein coding gene Chr8:86344164-86444945 (-)
LP/J MGP_LPJ_G0033833
 protein coding gene Chr8:91534413-91641725 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033731
 protein coding gene Chr8:100446997-100551750 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034440
 protein coding gene Chr8:90409676-90515152 (-)
PWK/PhJ MGP_PWKPhJ_G0032645
 protein coding gene Chr8:86688746-86792620 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032482
 protein coding gene Chr8:89258771-89366877 (-)
WSB/EiJ MGP_WSBEiJ_G0033055
 protein coding gene Chr8:90867423-90974617 (-)



Homology
more
  • Human Ortholog
    TOX3, TOX high mobility group box family member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOX3, TOX high mobility group box family member 3
  • Synonyms
    CAGF9, TNRC9
  • Links
    NCBI Gene ID: 27324
    neXtProt AC: NX_O15405
    UniProt: O15405

  • Chr Location
    16q12.1; chr16:52436416-52547802 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1108
  • Tissues
    117
  • cDNA Data
    25
  • Literature Summary
    17
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043668 Ensembl Gene Model | MGI Sequence Detail 101304 C57BL/6J ±  kb
transcript ENSMUST00000109621 Ensembl | MGI Sequence Detail 3356 Not Applicable  
polypeptide ENSMUSP00000105250 Ensembl | MGI Sequence Detail 575 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000031301 TOX high mobility group box family member 3
    (term hierarchy)
  • InterPro Domains
    IPR009071 High mobility group box domain
    IPR036910 High mobility group box domain superfamily
    IPR051365 TOX high mobility group box domain-containing protein
Molecular
Reagents
less
  • All nucleic 30
    cDNA 26
    Primer pair 3
    Other 1

    Microarray probesets 1
Other
Accession IDs
less
MGI:3573728
References
more
  • Summaries
    All 55
    Developmental Gene Expression 17
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:91257 Gray PA, et al., Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory