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Del(8Col4a1-Col4a2)1Epo
Targeted Allele Detail
Summary
Symbol: Del(8Col4a1-Col4a2)1Epo
Name: deletion, Chr8, Ernst Poschl 1; deletion, Chr 8, Ernst Poschl 1
MGI ID: MGI:3041149
Synonyms: Col4a1/Col4a2tm1Epo
Gene: Del(8Col4a1-Col4a2)1Epo  Location: unknown  Genetic Position: Chr8, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89190
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion, Intragenic deletion
  Del(8Col4a1-Col4a2)1Epo involves 2 genes/genome features (Col4a1, Col4a2) View all
 
Mutation details: Exon 1 of Col4a1 and exons 1-3 of Col4a2 were replaced with a neo cassette. RT-PCR indicated lack of mRNA for both genes in homozygous mutant mice embryos. (J:89190)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 38 assay results
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(8Col4a1-Col4a2)1Epo Mutation:  0 strains or lines available
References
Original:  J:89190 Poschl E, et al., Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development. Development. 2004 Apr;131(7):1619-28
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory