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Wipf3 Gene Detail
Summary
  • Symbol
    Wipf3
  • Name
    WAS/WASL interacting protein family, member 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3044681
    NCBI Gene: 330319
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:54406588-54480753 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 26.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2436 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3044681
 protein coding gene Chr6:54406206-54480753 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030760
 protein coding gene Chr6:53781373-53858894 (+)
A/J MGP_AJ_G0030729
 protein coding gene Chr6:51290948-51366421 (+)
AKR/J MGP_AKRJ_G0030656
 protein coding gene Chr6:53032643-53109221 (+)
BALB/cJ MGP_BALBcJ_G0030741
 protein coding gene Chr6:51642649-51717012 (+)
C3H/HeJ MGP_C3HHeJ_G0030454
 protein coding gene Chr6:53048116-53127500 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031196
 protein coding gene Chr6:54982164-55059615 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028402
 protein coding gene Chr6:48896941-48974297 (+)
CAST/EiJ MGP_CASTEiJ_G0029857
 protein coding gene Chr6:52894986-52977634 (+)
CBA/J MGP_CBAJ_G0030428
 protein coding gene Chr6:57242199-57324380 (+)
DBA/2J MGP_DBA2J_G0030578
 protein coding gene Chr6:51192688-51266776 (+)
FVB/NJ MGP_FVBNJ_G0030530
 protein coding gene Chr6:50777762-50852677 (+)
LP/J MGP_LPJ_G0030663
 protein coding gene Chr6:53729415-53804860 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030564
 protein coding gene Chr6:59773621-59862014 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031226
 protein coding gene Chr6:52979784-53059730 (+)
PWK/PhJ MGP_PWKPhJ_G0029570
 protein coding gene Chr6:50843714-50918631 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029404
 protein coding gene Chr6:52354402-52434772 (+)
WSB/EiJ MGP_WSBEiJ_G0029934
 protein coding gene Chr6:53008413-53084404 (+)



Homology
more
  • Human Ortholog
    WIPF3, WAS/WASL interacting protein family member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WIPF3, WAS/WASL interacting protein family member 3
  • Synonyms
    CR16
  • Links
    NCBI Gene ID: 644150
    neXtProt AC: NX_A6NGB9
    UniProt: A6NGB9

  • Chr Location
    7p14.3; chr7:29806486-29917061 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display impaired spermatogenesis, abnormal sperm head morphology, and significantly reduced male fertility. Female fertility is not affected.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000086040 Ensembl Gene Model | MGI Sequence Detail 74166 C57BL/6J ±  kb
    transcript ENSMUST00000132855 Ensembl | MGI Sequence Detail 4516 Not Applicable  
    polypeptide ENSMUSP00000120240 Ensembl | MGI Sequence Detail 483 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2141631
    References
    more
    • Summaries
      All 23
      Gene Ontology 5
      Phenotypes 5
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:317350 O'Neil SD, et al., Action potential-coupled Rho GTPase signaling drives presynaptic plasticity. Elife. 2021 Jul 16;10:e63756
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory