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Impg2 Gene Detail
Summary
  • Symbol
    Impg2
  • Name
    interphotoreceptor matrix proteoglycan 2
  • Synonyms
    IPM200, PG10.2, Spacrcan
  • Feature Type
    protein coding gene
  • IDs
    MGI:3044955
    NCBI Gene: 224224
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:56024676-56094119 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 33.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2214 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3044955
 protein coding gene Chr16:56019447-56094119 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022888
 protein coding gene Chr16:55313745-55392036 (+)
A/J MGP_AJ_G0022855
 protein coding gene Chr16:52938405-53008756 (+)
AKR/J MGP_AKRJ_G0022827
 protein coding gene Chr16:54620014-54693961 (+)
BALB/cJ MGP_BALBcJ_G0022855
 protein coding gene Chr16:53039410-53112905 (+)
C3H/HeJ MGP_C3HHeJ_G0022618
 protein coding gene Chr16:54806469-54887679 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023303
 protein coding gene Chr16:56879262-56953406 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020814
 protein coding gene Chr16:52642226-52709198 (+)
CAST/EiJ MGP_CASTEiJ_G0022145
 protein coding gene Chr16:55189499-55269878 (+)
CBA/J MGP_CBAJ_G0022591
 protein coding gene Chr16:59143966-59215692 (+)
DBA/2J MGP_DBA2J_G0022723
 protein coding gene Chr16:52703417-52772954 (+)
FVB/NJ MGP_FVBNJ_G0022698
 protein coding gene Chr16:52460711-52530718 (+)
LP/J MGP_LPJ_G0022790
 protein coding gene Chr16:55119779-55197295 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022716
 protein coding gene Chr16:59468964-59553229 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023318
 protein coding gene Chr16:54778864-54852112 (+)
PWK/PhJ MGP_PWKPhJ_G0021884
 protein coding gene Chr16:53022209-53098679 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021714
 protein coding gene Chr16:54555006-54627285 (+)
WSB/EiJ MGP_WSBEiJ_G0022189
 protein coding gene Chr16:54798943-54874865 (+)



Homology
more
  • Human Ortholog
    IMPG2, interphotoreceptor matrix proteoglycan 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IMPG2, interphotoreceptor matrix proteoglycan 2
  • Synonyms
    IPM200, RP56, SPACRCAN, VMD5
  • Links
    NCBI Gene ID: 50939
    neXtProt AC: NX_Q9BZV3
    UniProt: Q9BZV3

  • Chr Location
    3q12.3; chr3:101222546-101320575 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Impg2 mouse models; 2 with human IMPG2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 4 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null alleles display retinal abnormalities with reduced scotopic and photopic responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    6
  • cDNA Data
    21
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035270 Ensembl Gene Model | MGI Sequence Detail 69444 C57BL/6J ±  kb
    transcript ENSMUST00000069936 Ensembl | MGI Sequence Detail 6890 Not Applicable  
    polypeptide ENSMUSP00000063648 Ensembl | MGI Sequence Detail 1243 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 1
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:90863 Chen Q, et al., SPACRCAN in the interphotoreceptor matrix of the mouse retina: molecular, developmental and promoter analysis. Exp Eye Res. 2003 Jan;76(1):1-14
    • Latest
      J:346749 Williams BN, et al., Heterogeneity in the progression of retinal pathologies in mice harboring patient mimicking Impg2 mutations. Hum Mol Genet. 2024 Feb 18;33(5):448-464
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory