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Zc3h12d Gene Detail
Summary
  • Symbol
    Zc3h12d
  • Name
    zinc finger CCCH type containing 12D
  • Synonyms
    D730019B10Rik, TFL
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045313
    NCBI Gene: 237256
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:7708234-7746160 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 2.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1275 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045313
 protein coding gene Chr10:7708087-7746161 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017001
 protein coding gene Chr10:5060425-5103682 (+)
A/J MGP_AJ_G0016979
 protein coding gene Chr10:4813497-4851800 (+)
AKR/J MGP_AKRJ_G0016943
 protein coding gene Chr10:4908515-4948592 (+)
BALB/cJ MGP_BALBcJ_G0016937
 protein coding gene Chr10:4784419-4822816 (+)
C3H/HeJ MGP_C3HHeJ_G0016762
 protein coding gene Chr10:5040583-5086504 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017399
 protein coding gene Chr10:5184491-5238077 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015104
 protein coding gene Chr10:4406461-4438171 (+)
CAST/EiJ MGP_CASTEiJ_G0016344
 protein coding gene Chr10:4955714-5008438 (+)
CBA/J MGP_CBAJ_G0016734
 protein coding gene Chr10:5336552-5382392 (+)
DBA/2J MGP_DBA2J_G0016842
 protein coding gene Chr10:4740697-4779432 (+)
FVB/NJ MGP_FVBNJ_G0016837
 protein coding gene Chr10:4687877-4726433 (+)
LP/J MGP_LPJ_G0016917
 protein coding gene Chr10:4906141-4944505 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016867
 protein coding gene Chr10:5290675-5335408 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017437
 protein coding gene Chr10:4859300-4898897 (+)
PWK/PhJ MGP_PWKPhJ_G0016129
 protein coding gene Chr10:4717587-4756255 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015911
 protein coding gene Chr10:4942584-4979432 (+)
WSB/EiJ MGP_WSBEiJ_G0016406
 protein coding gene Chr10:4862329-4902510 (+)



Homology
more
  • Human Ortholog
    ZC3H12D, zinc finger CCCH-type containing 12D
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZC3H12D, zinc finger CCCH-type containing 12D
  • Synonyms
    C6orf95, dJ281H8.1, MCPIP4, p34, TFL
  • Links
    NCBI Gene ID: 340152
    neXtProt AC: NX_A2A288
    UniProt: A2A288

  • Chr Location
    chr6:149446795-149485014 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit disrupted regulation of excessive inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039981 Ensembl Gene Model | MGI Sequence Detail 37927 C57BL/6J ±  kb
    transcript ENSMUST00000039484 Ensembl | MGI Sequence Detail 4092 Not Applicable  
    polypeptide ENSMUSP00000040217 Ensembl | MGI Sequence Detail 533 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 2
    References
    more
    • Summaries
      All 33
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:140125 Liang J, et al., Genome-wide survey and expression profiling of CCCH-zinc finger family reveals a functional module in macrophage activation. PLoS One. 2008;3(8):e2880
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory