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Ccin Gene Detail
Summary
  • Symbol
    Ccin
  • Name
    calicin
  • Synonyms
    4933417A14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045316
    NCBI Gene: 442829
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:43983483-43985423 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 23.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    153 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045316
 protein coding gene Chr4:43983483-43985533 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028230
 protein coding gene Chr4:42116213-42118153 (+)
A/J MGP_AJ_G0028187
 protein coding gene Chr4:40625652-40627592 (+)
AKR/J MGP_AKRJ_G0028139
 protein coding gene Chr4:41580589-41582529 (+)
BALB/cJ MGP_BALBcJ_G0028207
 protein coding gene Chr4:40722547-40724487 (+)
C3H/HeJ MGP_C3HHeJ_G0027929
 protein coding gene Chr4:42192599-42194539 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028648
 protein coding gene Chr4:43730441-43732381 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025958
 protein coding gene Chr4:38060715-38062655 (+)
CAST/EiJ MGP_CASTEiJ_G0027368
 protein coding gene Chr4:41710936-41712876 (+)
CBA/J MGP_CBAJ_G0027895
 protein coding gene Chr4:45077384-45079324 (+)
DBA/2J MGP_DBA2J_G0028044
 protein coding gene Chr4:40535954-40537894 (+)
FVB/NJ MGP_FVBNJ_G0028011
 protein coding gene Chr4:39767177-39769117 (+)
LP/J MGP_LPJ_G0028143
 protein coding gene Chr4:42199788-42201728 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028035
 protein coding gene Chr4:48279243-48281183 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028684
 protein coding gene Chr4:41791284-41793224 (+)
PWK/PhJ MGP_PWKPhJ_G0027092
 protein coding gene Chr4:40583641-40585581 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026921
 protein coding gene Chr4:41315828-41317768 (+)
WSB/EiJ MGP_WSBEiJ_G0027446
 protein coding gene Chr4:41668908-41670848 (+)



Homology
more
  • Human Ortholog
    CCIN, calicin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCIN, calicin
  • Synonyms
    BTBD20, KBTBD14, SPGF91
  • Links
    NCBI Gene ID: 881
    neXtProt AC: NX_Q13939
    UniProt: Q13939

  • Chr Location
    9p13.3; chr9:36169388-36171334 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CCIN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit male infertility associated with oligozoospermia, asthenozoospermia, defective acroplaxome structure, and increased male germ cell apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000070999 Ensembl Gene Model | MGI Sequence Detail 1941 C57BL/6J ±  kb
    transcript ENSMUST00000095107 Ensembl | MGI Sequence Detail 1941 Not Applicable  
    polypeptide ENSMUSP00000092725 Ensembl | MGI Sequence Detail 588 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 2
    References
    more
    • Summaries
      All 23
      Gene Ontology 4
      Phenotypes 4
    • Earliest
      J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
    • Latest
      J:352417 Fan Y, et al., Mutations in CCIN cause teratozoospermia and male infertility. Sci Bull (Beijing). 2022 Oct 31;67(20):2112-2123
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory