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Nup85 Gene Detail
Summary
  • Symbol
    Nup85
  • Name
    nucleoporin 85
  • Synonyms
    frount, Pcnt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3046173
    NCBI Gene: 445007
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:115455264-115474750 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 80.87 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    395 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3046173
 protein coding gene Chr11:115455260-115474811 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019393
 protein coding gene Chr11:119604213-119624347 (+)
A/J MGP_AJ_G0019362
 protein coding gene Chr11:114380915-114400835 (+)
AKR/J MGP_AKRJ_G0019332
 protein coding gene Chr11:117785559-117803794 (+)
BALB/cJ MGP_BALBcJ_G0019336
 protein coding gene Chr11:114797241-114817945 (+)
C3H/HeJ MGP_C3HHeJ_G0019142
 protein coding gene Chr11:118151978-118169158 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019786
 protein coding gene Chr11:123254127-123276227 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017409
 protein coding gene Chr11:111409306-111425610 (+)
CAST/EiJ MGP_CASTEiJ_G0018697
 protein coding gene Chr11:119464285-119487447 (+)
CBA/J MGP_CBAJ_G0019114
 protein coding gene Chr11:128125321-128150965 (+)
DBA/2J MGP_DBA2J_G0019225
 protein coding gene Chr11:113808739-113831498 (+)
FVB/NJ MGP_FVBNJ_G0019217
 protein coding gene Chr11:113299283-113320396 (+)
LP/J MGP_LPJ_G0019295
 protein coding gene Chr11:119989320-120009509 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019250
 protein coding gene Chr11:127271402-127293086 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019824
 protein coding gene Chr11:118443085-118467790 (+)
PWK/PhJ MGP_PWKPhJ_G0018461
 protein coding gene Chr11:115099740-115119534 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018254
 protein coding gene Chr11:118195588-118215850 (+)
WSB/EiJ MGP_WSBEiJ_G0018749
 protein coding gene Chr11:118409766-118431952 (+)



Homology
more
  • Human Ortholog
    NUP85, nucleoporin 85
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUP85, nucleoporin 85
  • Synonyms
    FROUNT, NPHS17, Nup75
  • Links
    NCBI Gene ID: 79902
    neXtProt AC: NX_Q9BW27
    UniProt: Q9BW27

  • Chr Location
    17q25.1; chr17:75205659-75235758 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NUP85 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inducible KO decreases macrophage and monocyte population in tumors, reducing tumor growth and metastasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    9
  • cDNA Data
    123
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 445007 NCBI Gene Model | MGI Sequence Detail 19487 C57BL/6J ±  kb
transcript NM_001002929 RefSeq | MGI Sequence Detail 2181 C57BL/6  
polypeptide Q8R480 UniProt | EBI | MGI Sequence Detail 656 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 123
    cDNA 123

    Microarray probesets 2
References
more
  • Summaries
    All 38
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 12
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory