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Pappa2 Gene Detail
Summary
  • Symbol
    Pappa2
  • Name
    pappalysin 2
  • Synonyms
    PAPP-A2, Pappe, PLAC3, placenta-specific 3, pregnancy-associated plasma preproprotein-A2, pregnancy-associated plasma protein-E
  • Feature Type
    protein coding gene
  • IDs
    MGI:3051647
    NCBI Gene: 23850
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:158539297-158788019 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 68.49 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5915 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3051647
 protein coding gene Chr1:158539297-158808060 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016636
 protein coding gene Chr1:163816607-164104591 (-)
A/J MGP_AJ_G0016617
 protein coding gene Chr1:157177472-157442487 (-)
AKR/J MGP_AKRJ_G0016583
 protein coding gene Chr1:161983954-162264096 (-)
BALB/cJ MGP_BALBcJ_G0016578
 protein coding gene Chr1:157701872-157963469 (-)
C3H/HeJ MGP_C3HHeJ_G0016402
 protein coding gene Chr1:162134657-162416173 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017039
 protein coding gene Chr1:169418090-169713019 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014748
 protein coding gene Chr1:149343148-149605194 (-)
CAST/EiJ MGP_CASTEiJ_G0015982
 protein coding gene Chr1:161714794-162006884 (-)
CBA/J MGP_CBAJ_G0016377
 protein coding gene Chr1:175392712-175695536 (-)
DBA/2J MGP_DBA2J_G0016483
 protein coding gene Chr1:156130272-156393525 (-)
FVB/NJ MGP_FVBNJ_G0016481
 protein coding gene Chr1:154578471-154857210 (-)
LP/J MGP_LPJ_G0016554
 protein coding gene Chr1:164916307-165205070 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016506
 protein coding gene Chr1:182942269-183238776 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017075
 protein coding gene Chr1:161829037-162118400 (-)
PWK/PhJ MGP_PWKPhJ_G0015768
 protein coding gene Chr1:155259386-155530362 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0016044
 protein coding gene Chr1:161944909-162232524 (-)



Homology
more
  • Human Ortholog
    PAPPA2, pappalysin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAPPA2, pappalysin 2
  • Synonyms
    PAPP-A2, PAPP-E, PAPPE, PLAC3, SSDA
  • Links
    NCBI Gene ID: 60676
    neXtProt AC: NX_Q9BXP8
    UniProt: Q9BXP8

  • Chr Location
    1q25.2; chr1:176463171-176845601 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 7 alleles in 7 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation are viable and fertile but display postnatal growth retardation that is more pronounced in females compared to males.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    932
  • Tissues
    136
  • cDNA Data
    35
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23850 NCBI Gene Model | MGI Sequence Detail 248723 C57BL/6J ±  kb
    transcript NM_001085376 RefSeq | MGI Sequence Detail 8975 C57BL/6  
    polypeptide NP_001078845 RefSeq | MGI Sequence Detail 1789 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR036116 Fibronectin type III superfamily
      IPR006558 LamG-like jellyroll fold
      IPR024079 Metallopeptidase, catalytic domain superfamily
      IPR011936 Myxococcus cysteine-rich repeat
      IPR000800 Notch domain
      IPR043543 Pappalysin-1/2
      IPR008754 Peptidase M43, pregnancy-associated plasma-A
      IPR000436 Sushi/SCR/CCP domain
      IPR035976 Sushi/SCR/CCP superfamily
    • GlyGen
      E9PZ87 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 37
      Primer pair 3
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 11
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:6660 Rougeon F, et al., Molecular cloning of a mouse submaxillary gland renin cDNA fragment. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6367-71
    • Latest
      J:327983 Wang J, et al., Placenta-specific lncRNA 1600012P17Rik is expressed in spongiotrophoblast and glycogen trophoblast cells of mouse placenta. Histochem Cell Biol. 2022 Jul;158(1):65-78
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory