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Kcnk9 Gene Detail
Summary
  • Symbol
    Kcnk9
  • Name
    potassium channel, subfamily K, member 9
  • Synonyms
    Task3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3521816
    NCBI Gene: 223604
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:72372938-72418189 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 33.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    881 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3521816
 protein coding gene Chr15:72372938-72422415 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021916
 protein coding gene Chr15:72195654-72229750 (-)
A/J MGP_AJ_G0021875
 protein coding gene Chr15:69618774-69654026 (-)
AKR/J MGP_AKRJ_G0021857
 protein coding gene Chr15:71403711-71436927 (-)
BALB/cJ MGP_BALBcJ_G0021882
 protein coding gene Chr15:69629011-69662025 (-)
C3H/HeJ MGP_C3HHeJ_G0021655
 protein coding gene Chr15:71542806-71580016 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022321
 protein coding gene Chr15:74964917-75010976 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019858
 protein coding gene Chr15:66074414-66107906 (-)
CAST/EiJ MGP_CASTEiJ_G0021174
 protein coding gene Chr15:72273681-72326444 (-)
CBA/J MGP_CBAJ_G0021621
 protein coding gene Chr15:77425892-77461284 (-)
DBA/2J MGP_DBA2J_G0021746
 protein coding gene Chr15:69235335-69268622 (-)
FVB/NJ MGP_FVBNJ_G0021728
 protein coding gene Chr15:68236575-68270758 (-)
LP/J MGP_LPJ_G0021818
 protein coding gene Chr15:72232593-72270631 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021751
 protein coding gene Chr15:82813701-82849125 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022343
 protein coding gene Chr15:71793587-71831470 (-)
PWK/PhJ MGP_PWKPhJ_G0020915
 protein coding gene Chr15:69293005-69346286 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020756
 protein coding gene Chr15:71672258-71705460 (-)
WSB/EiJ MGP_WSBEiJ_G0021226
 protein coding gene Chr15:71767292-71801319 (-)



Homology
more
  • Human Ortholog
    KCNK9, potassium two pore domain channel subfamily K member 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNK9, potassium two pore domain channel subfamily K member 9
  • Synonyms
    BIBARS, K2p9.1, KT3.2, TASK-3, TASK3, TASK32
  • Links
    NCBI Gene ID: 51305
    neXtProt AC: NX_Q9NPC2
    UniProt: Q9NPC2

  • Chr Location
    8q24.3; chr8:139600838-139704109 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KCNK9 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 4 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased pH sensitive action potential in serotonergic neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    24
  • cDNA Data
    4
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036760 Ensembl Gene Model | MGI Sequence Detail 45252 C57BL/6J ±  kb
transcript ENSMUST00000044624 Ensembl | MGI Sequence Detail 12300 Not Applicable  
polypeptide ENSMUSP00000038729 Ensembl | MGI Sequence Detail 402 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000002079 potassium channel subfamily K member 9
    (term hierarchy)
  • InterPro Domains
    IPR013099 Potassium channel domain
    IPR005407 Potassium channel subfamily K member 9
    IPR003280 Two pore domain potassium channel
    IPR003092 Two pore domain potassium channel, TASK family
  • GlyGen
    Q3LS21 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 7
    cDNA 5
    Primer pair 2

    Microarray probesets 1
References
more
  • Summaries
    All 95
    Developmental Gene Expression 4
    Diseases 2
    Gene Ontology 14
    Phenotypes 62
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:330854 Wen X, et al., Tandem pore domain acid-sensitive K channel 3 (TASK-3) regulates visual sensitivity in healthy and aging retina. Sci Adv. 2022 Sep 9;8(36):eabn8785
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory