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Wfdc6b Gene Detail
Summary
  • Symbol
    Wfdc6b
  • Name
    WAP four-disulfide core domain 6B
  • Synonyms
    Wfdc6
  • Feature Type
    protein coding gene
  • IDs
    MGI:3575430
    NCBI Gene: 433502
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164455442-164460132 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    289 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3575430
 protein coding gene Chr2:164455431-164460133 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026859
 protein coding gene Chr2:170036119-170041472 (-)
A/J MGP_AJ_G0026826
 protein coding gene Chr2:163113188-163118264 (-)
AKR/J MGP_AKRJ_G0026798
 protein coding gene Chr2:167989212-168003220 (+)
BALB/cJ MGP_BALBcJ_G0026834
 protein coding gene Chr2:163474140-163479216 (-)
C3H/HeJ MGP_C3HHeJ_G0026578
 protein coding gene Chr2:168351934-168361943 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027284
 protein coding gene Chr2:175022363-175027314 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024655
 protein coding gene Chr2:156540850-156561694 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0026556
 protein coding gene Chr2:181360640-181377021 (+)
DBA/2J MGP_DBA2J_G0026694
 protein coding gene Chr2:162314627-162319306 (+)
FVB/NJ MGP_FVBNJ_G0026660
 protein coding gene Chr2:160734400-160739079 (+)
LP/J MGP_LPJ_G0026796
 protein coding gene Chr2:170165223-170170320 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0027339
 protein coding gene Chr2:167864638-167871356 (-)
PWK/PhJ MGP_PWKPhJ_G0025769
 protein coding gene Chr2:161828821-161832858 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0026107
 protein coding gene Chr2:168729071-168734138 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070531 Ensembl Gene Model | MGI Sequence Detail 4691 C57BL/6J ±  kb
transcript ENSMUST00000094346 Ensembl | MGI Sequence Detail 984 Not Applicable  
polypeptide ENSMUSP00000091906 Ensembl | MGI Sequence Detail 148 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000033562 WAP four-disulfide core domain protein 6B
    (term hierarchy)
  • InterPro Domains
    IPR036645 Elafin-like superfamily
    IPR002223 Pancreatic trypsin inhibitor Kunitz domain
    IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamily
    IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
    IPR051388 Serine protease inhibitor and venom toxin
    IPR008197 WAP-type 'four-disulfide core' domain
Molecular
Reagents
less
  • All nucleic 1
    cDNA 1

    Microarray probesets 1
References
more
  • Summaries
    All 18
    Gene Ontology 3
    Phenotypes 1
  • Earliest
    J:99265 Clauss A, et al., The evolution of a genetic locus encoding small serine proteinase inhibitors. Biochem Biophys Res Commun. 2005 Jul 29;333(2):383-9
  • Latest
    J:300068 Andrade AD, et al., Lipopolysaccharide-induced epididymitis modifies the transcriptional profile of Wfdc genes in mice. Biol Reprod. 2021 Jan 4;104(1):144-158
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory