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Ugt1a8 Gene Detail
Summary
  • Symbol
    Ugt1a8
  • Name
    UDP glucuronosyltransferase 1 family, polypeptide A8
  • Synonyms
    A116, OTTMUSG00000020811
  • Feature Type
    protein coding gene
  • IDs
    MGI:3576090
    NCBI Gene: 613123
  • Member of
    Ugt1 cluster
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:88015550-88146720 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 44.50 cM
Strain
Comparison
more
  • SNPs within 2kb
    3662 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3576090
 protein coding gene Chr1:88015535-88146726 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016275
 protein coding gene Chr1:89483440-89628384 (+)
A/J MGP_AJ_G0016256
 protein coding gene Chr1:86144130-86334105 (+)
AKR/J MGP_AKRJ_G0016217
 protein coding gene Chr1:88702638-88898486 (+)
BALB/cJ MGP_BALBcJ_G0016213
 protein coding gene Chr1:86299311-86472417 (+)
C3H/HeJ MGP_C3HHeJ_G0016041
 protein coding gene Chr1:88959274-89122344 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016671
 protein coding gene Chr1:92818567-92996661 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014392
 protein coding gene Chr1:80649947-80707874 (+)
CAST/EiJ MGP_CASTEiJ_G0015627
 protein coding gene Chr1:88168458-88339179 (+)
CBA/J MGP_CBAJ_G0016017
 protein coding gene Chr1:95799794-95995698 (+)
DBA/2J MGP_DBA2J_G0016120
 protein coding gene Chr1:85426769-85575540 (+)
FVB/NJ MGP_FVBNJ_G0016119
 protein coding gene Chr1:84506286-84658652 (+)
LP/J MGP_LPJ_G0016191
 protein coding gene Chr1:90530543-90703616 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016145
 protein coding gene Chr1:99042603-99344403 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016713
 protein coding gene Chr1:88790422-88953955 (+)
PWK/PhJ MGP_PWKPhJ_G0015413
 protein coding gene Chr1:84774315-84935769 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015193
 protein coding gene Chr1:87726363-87876024 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    UGT1A10, UDP glucuronosyltransferase family 1 member A10
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UGT1A10, UDP glucuronosyltransferase family 1 member A10
  • Synonyms
    GNT1, hUG-BR1, UDPGT, UGT1, UGT1-01, UGT1.1, UGT1-10, UGT1.10, UGT-1A, UGT1A, UGT1A1, UGT-1J, UGT1J
  • Links
    NCBI Gene ID: 54575
    neXtProt AC: NX_Q9HAW8
    UniProt: Q9HAW8

  • Chr Location
    2q37.1; chr2:233636448-233773300 (+)  GRCh38
  • Human Ortholog
    UGT1A7, UDP glucuronosyltransferase family 1 member A7
  • Synonyms
    GNT1, hUG-BR1, UDPGT, UDPGT 1-7, UGT1, UGT1-01, UGT1-07, UGT1.1, UGT1.7, UGT-1A, UGT1A, UGT1A1, UGT-1G, UGT1G
  • Links
    NCBI Gene ID: 54577
    neXtProt AC: NX_Q9HAW7
    UniProt: Q9HAW7

  • Chr Location
    2q37.1; chr2:233681901-233773300 (+)  GRCh38
  • Human Ortholog
    UGT1A8, UDP glucuronosyltransferase family 1 member A8
  • Synonyms
    GNT1, hUG-BR1, UDPGT, UDPGT 1-1, UDPGT 1-8, UGT1, UGT1-01, UGT1-08, UGT1.1, UGT1.8, UGT-1A, UGT1A, UGT1A1, UGT1A8S, UGT-1H, UGT1H
  • Links
    NCBI Gene ID: 54576
    neXtProt AC: NX_Q9HAW9
    UniProt: Q9HAW9

  • Chr Location
    2q37.1; chr2:233617633-233773300 (+)  GRCh38
  • Human Ortholog
    UGT1A9, UDP glucuronosyltransferase family 1 member A9
  • Synonyms
    HLUGP4, LUGP4, UDPGT, UDPGT 1-9, UGT1-09, UGT1-9, UGT1.9, UGT1A9S, UGT1AI, UGT-1I, UGT1I
  • Links
    NCBI Gene ID: 54600
    neXtProt AC: NX_O60656
    UniProt: O60656

  • Chr Location
    2q37.1; chr2:233671898-233773300 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human UGT1A7 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
  • All Sequences
    25
  • RefSeq
    2
  • UniProt
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic 613123 NCBI Gene Model | MGI Sequence Detail 131171 C57BL/6J ±  kb
transcript NM_001378375 RefSeq | MGI Sequence Detail 2206 C57BL/6  
polypeptide NP_001365304 RefSeq | MGI Sequence Detail 530 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • EC
    2.4.1.17
  • InterPro Domains
    IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase
    IPR050271 UDP-glycosyltransferase
    IPR035595 UDP-glycosyltransferase family, conserved site
Molecular
Reagents
less
  • All nucleic 1
    Genomic 1
Other
Accession IDs
less
MGI:3707579
References
more
  • Summaries
    All 15
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:7938 Juriloff DM, et al., Genetic and developmental studies of a new mouse mutation that produces otocephaly. J Craniofac Genet Dev Biol. 1985;5(2):121-45
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory