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Tor1aip2 Gene Detail
Summary
  • Symbol
    Tor1aip2
  • Name
    torsin A interacting protein 2
  • Synonyms
    1110020D10Rik, 15kDa, Ifrg15, LULL1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3582695
    NCBI Gene: 240832
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:155911410-155944607 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 67.70 cM, cytoband G3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    844 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3582695
 protein coding gene Chr1:155911149-155944607 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016619
 protein coding gene Chr1:160996620-161031373 (+)
A/J MGP_AJ_G0016600
 protein coding gene Chr1:154534424-154572407 (+)
AKR/J MGP_AKRJ_G0016566
 protein coding gene Chr1:159262354-159297548 (+)
BALB/cJ MGP_BALBcJ_G0016561
 protein coding gene Chr1:155038338-155072222 (+)
C3H/HeJ MGP_C3HHeJ_G0016385
 protein coding gene Chr1:159386984-159422831 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017022
 protein coding gene Chr1:166530259-166563476 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014731
 protein coding gene Chr1:146750296-146784047 (+)
CAST/EiJ MGP_CASTEiJ_G0015965
 protein coding gene Chr1:158929404-158963072 (+)
CBA/J MGP_CBAJ_G0016360
 protein coding gene Chr1:172367524-172410356 (+)
DBA/2J MGP_DBA2J_G0016466
 protein coding gene Chr1:153497840-153531685 (+)
FVB/NJ MGP_FVBNJ_G0016464
 protein coding gene Chr1:151958526-151992229 (+)
LP/J MGP_LPJ_G0016537
 protein coding gene Chr1:162135529-162171244 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016489
 protein coding gene Chr1:179958136-180005456 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017058
 protein coding gene Chr1:159068689-159102978 (+)
PWK/PhJ MGP_PWKPhJ_G0015751
 protein coding gene Chr1:152570502-152605308 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015538
 protein coding gene Chr1:157820709-157854946 (+)
WSB/EiJ MGP_WSBEiJ_G0016027
 protein coding gene Chr1:159163552-159202278 (+)



Homology
more
  • Human Ortholog
    TOR1AIP2, torsin 1A interacting protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOR1AIP2, torsin 1A interacting protein 2
  • Synonyms
    IFRG15, LULL1, NET9
  • Links
    NCBI Gene ID: 163590
    neXtProt AC: NX_Q8NFQ8, NX_Q9H496
    UniProt: Q8NFQ8, Q9H496

  • Chr Location
    1q25.2; chr1:179839967-179877803 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Mice with loss of expression in the liver are viable and do not develop hepatic steatosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    787
  • Tissues
    52
  • cDNA Data
    32
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 240832 NCBI Gene Model | MGI Sequence Detail 33198 C57BL/6J ±  kb
transcript NM_172843 RefSeq | MGI Sequence Detail 5857 C57BL/6  
polypeptide Q8BYU6 UniProt | EBI | MGI Sequence Detail 502 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000016552 torsin-1A-interacting protein 2
    (term hierarchy)
  • InterPro Domains
    IPR038599 LAP1C-like, C-terminal domain superfamily
    IPR008662 Torsin-1A-interacting protein 1/2
    IPR046753 Torsin-1A-interacting protein 1/2, AAA+ activator domain
    IPR046754 Torsin-1A-interacting protein 1/2, N-terminal
  • GlyGen
    Q8BYU6 5 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (2 sites)
Molecular
Reagents
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  • All nucleic 36
    cDNA 34
    Primer pair 1
    Other 1

    Microarray probesets 11
Other
Accession IDs
less
MGI:1915073, MGI:1929890, MGI:2138554, MGI:2138622, MGI:2138663, MGI:3034941
References
more
  • Summaries
    All 46
    Developmental Gene Expression 6
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:345574 Hernandez-Ono A, et al., Dynamic regulation of hepatic lipid metabolism by torsinA and its activators. JCI Insight. 2024 Jan 9;:e175328
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory